Effects of catecholamines on isolated canine facial veins.
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概要
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The buccal segment of the canine facial vein which was precontracted moderately with prostaglandin F<SUB>2α</SUB> relaxed to different extents in response to dopamine (DA), norepinephrine (NE), epinephrine (Epi) and isoproterenol (Isp). Propranolol (10<SUP>-6</SUP>M) reversed the relaxation responses to contractions. In the presence of an α-adrenoceptor blockade and inhibitors of neuronal and extraneuronal uptakes, the four catecholamines relaxed the vein fully, and the order of pD<SUB>2</SUB> values was Isp (8.34) > Epi (7.53) ≅ NE (7.50) >> DA (5.31). The results indicate that in the canine facial vein, β-adrenoceptors predominate over α-adrenoceptors, and the subtype of β-adrenoceptor may be the β<SUB>1</SUB>-type.
- 公益社団法人 日本薬理学会の論文
著者
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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Negita Sumiko
Department of Pharmacology, Hiroshima University School of Medicine
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- Preface
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