Endothelium-Independent Relaxant Effect of 5-Hydroxytryptamine (5-HT) on the Isolated Rabbit Facial Vein
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概要
- 論文の詳細を見る
The facial vein in several species has been shown to have unusual properties, including exhibition of spontaneous myogenic tone and relaxation to norepinephrine (NE). The present study was undertaken to characterize the relaxant effect of 5-hydroxytryptamine (5-HT) on the rabbit facial vein. An isolated ring preparation of the rabbit facial vein exhibited intrinsic tone when it was stretched and the spontaneous contraction continued for hours. 5-HT concentration-dependently relaxed facial veins exhibiting spontaneous contraction. The relaxation was not inhibited by rubbing the endothelium or by N^G-nitro-L-arginine (10^<-4>M), a nitric oxide (NO) synthase inhibitor. The 5-HT-induced relaxation was also unaffected by pretreatment with indomethacin (10^<-5> M), a cyclooxygenase inhibitor, and propranolol (10^<-6> M), a both β-adrenoceptor and 5-HT_<1B>-receptor antagonist. In contrast, 5-HT-induced relaxation of the facial vein was concentration-dependently antagonized by methysergide (10^<-7> M and 10^<-6> M), a non-selective 5-H_1- and 5-HT_2-receptor antagonist, but not by NAN-190 (10^<-6> M) and SDZ-205,557 (10^<-6> M), antagonists for 5-HT_<1A>- and 5-HT_4-receptors, respectively. A higher (10^<-6> M), but not lower (3×10^<-7> M) concentration of ketanserin, a 5-HT_2-receptor antagonist, slightly inhibited the 5-HT-induced relaxation. These results indicate that 5-HT-induced relaxation is not due to indirect mechanisms mediated by NE released from the sympathetic nerve terminals, or by endogenous prostanoid and endothelium-derived relaxing factor (EDRF=NO) released from the vascular tissues, but due to a direct effect on the 5-HT receptors located on vascular smooth muscle cells. However, the subtype of 5-HT receptor that produces relaxation of the rabbit facial vein remains to be clarified.
- 日本平滑筋学会の論文
著者
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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UCHIYAMA Toshimitsu
Departments of Pharmacology Faculty of Medicine, Toho University
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Teranishi Y
広島大学 生理
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Teranishi Yasuhiro
Department Of Physiology School Of Medicine Hiroshima University
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Tsuru H
Department Of Pharmacology Toho University School Of Medicine
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NAKAI Shuzo
Department of Pharmacology, Toho University School of Medicine
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Teranishi Yasuhiro
Department Of Physiology Hiroshima University Faculty Of Medicine
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Nakai Shuzo
Department Of Pharmacology Toho University School Of Medicine
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Uchiyama Toshimitsu
Department Of Pharmacology Faculty Of Medicine Toho University
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- Preface
- DIFFERENT MODES OF ACTION OF CLONIDINE ON ISOLATED CANINE VEINS
- Are Sodium-Dependent V_1 Receptors and Sympathetic Nerve Activations Involved in Regulation of Blood Pressure in Borderline-Hypertensive Hiroshima Rats?
- Some Embryological Aspects of Cholinergic Innervation in the Cardiovascular System-A Close Association With the Subintestinal Circulatory Channel
- Contribution of Endogenous Vasopressin to Regional Hemodynamics in Borderline-Hypertensive Hirosima Rats
- Role of Perivascular Sympathetic Nerves and Regional Differences in the Features of Sympathetic Innervation of the Vascular System
- Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats
- Endothelium-Independent Relaxant Effect of 5-Hydroxytryptamine (5-HT) on the Isolated Rabbit Facial Vein
- CARDIOTONIC ACTION OF RING A-MODIFIED CARDENOLIDES, WITH SPECIAL REFERENCE TO CLEAVAGE OF THE RING
- RESPONSIVENESS OF ISOLATED DOG VEINS TO BRADYKININ: DISTRIBUTION AND A POSSIBLE CORRELATION WITH GENESIS OF THE VENOUS SYSTEM
- The participation of adenosine receptors in the adenosine 5'-triphosphate-induced relaxation in the isolated rabbit corpus cavernosum penis
- STIMULANT ACTION OF METHOXAMINE IN THE ISOLATED ATRIA OF NORMAL AND 6-PROPYL-2-THIOURACIL-FED RATS
- Hindquarter Sympathetic Tone Induced by Small Blood Loss in Conscious Rats
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- Alteration of autonomic responses in cardiovascular
- α_-Adrenoceptor Subtype Mediating the Phenylephrine-Induced Contractile Response in Rabbit Corpus Cavernosum Penis
- PARTICIPATION OF CATECHOLAMINE IN THE DIGITOXIGENIN-INDUCED CONTRACTION OF ISOLATED DOG VEINS
- Release of Sympathetic Neurotransmitter Evoked by Electrical Stimulation Is Increased in the Chronically Decentralized Artery.
- An extension of pA principle to the potentiation of drug effects, and its application to the biological assay of some anticholinesterases and cardenolides.
- Effects of catecholamines on isolated canine facial veins.
- Heterogeneity of .BETA.-adrenoceptor in canine veins: Comparison among the facial, portal and saphenous veins.
- Time course of the development of pre- and postjunctional supersensitivity in the rabbit ear artery after decentralization.
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