Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats
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概要
- 論文の詳細を見る
The interaction between [Arg8]-vasopressin and a vasopressin receptor antagonist, [d(CH2)51, O-Me-Tyr2, Arg8]-vasopressin, was examined in Hiroshima rats and normotensive control rats under pentobarbital anesthesia. [Arg8]-vasopressin dose-dependently increased the arterial pressure in both the Hiroshima and control rats, the pressor effect being greater in the Hiroshima rats. After the administration of a vasopressin antagonist (0.01 mg/kg), which by itself decreased arterial pressure only in the Hiroshima rats, the dose-response curve for [Arg8]-vasopressin was much more greatly shifted to the right in the control rats. These results indicate that with or without a vasopressin antagonist, the exogenous [Arg8]-vasopressin induced more powerful pressor actions in the Hiroshima rats compared to the control rats.
- 社団法人 日本薬理学会の論文
- 1999-02-01
著者
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Ozono Ryoji
Department Of Clinical Laboratory Medicine Hiroshima University Graduate School Of Biomedical Scienc
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Ozono Ryoji
First Department Of Internal Medicine Faculty Of Medicine Hiroshima University
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Tsuru Hiromichi
Department Of Pharmacology Faculty Of Medicine Toho University
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KUMAZAKI Tsutomu
Department of Biochemistry and Biophysics, Research Institute for Radiation Biology and Medicine
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Teranishi Yasuhiro
Second Department Of Physiology Hiroshima University
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Teranishi Yasuhiro
Department Of Physiology School Of Medicine Hiroshima University
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Tsuru H
Department Of Pharmacology Toho University School Of Medicine
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Teranishi Yasuhiro
Department Of Physiology Hiroshima University Faculty Of Medicine
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Kumazaki Tsutomu
Department Of Biochemistry And Biophysics Research Institute For Radiation Biology And Medicine
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- Some Embryological Aspects of Cholinergic Innervation in the Cardiovascular System-A Close Association With the Subintestinal Circulatory Channel
- Contribution of Endogenous Vasopressin to Regional Hemodynamics in Borderline-Hypertensive Hirosima Rats
- Role of Perivascular Sympathetic Nerves and Regional Differences in the Features of Sympathetic Innervation of the Vascular System
- Effects of Exogenous [Arg^8]-Vasopressin on Borderline-Hypertensive Hiroshima Rats
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