Inhalation of carbon dioxide enhances the coronary vasodilating action of isosorbide dinitrate in the dog.
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概要
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Two kinds of inspiratory gases, 100% O<SUB>2</SUB> and 81% O<SUB>2</SUB>+19% CO<SUB>2</SUB>, were used for the artificial respiration. Elevating the inspiratory CO<SUB>2</SUB> tension enhanced the decrease in coronary vascular resistance caused by isosorbide dinitrate (100 μg/kg), without any change in heart rate and systemic arterial pressure. Such a change in coronary vascular resistance was prevented by indomethacin. The results suggested an interaction between isosorbide dinitrate and CO<SUB>2</SUB>, which was mediated by prostaglandins.
- 公益社団法人 日本薬理学会の論文
著者
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Ishikawa Naohisa
Department Of Pharmacology Aichi Medical University School Of Medicine
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Nakamura Jiro
Department Of Metabolic Deseases Nagoya Graduate School Of Medicine
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ZHANG Shiwei
Department of Pharmacology, Nanjing College of Traditional Chinese Medicine
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