Ethanol inhibits vestibular and caloric nystagmus without affecting optokinetic nystagmus in rabbits.
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概要
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Effects of ethanol on optokinetic, vestibular and caloric nystagmus were investigated in pigmented rabbits to determine whether or not it affects a specific site involved in the induction of various nystagmus. Optokinetic nystagmus was produced by rotation of the drum with vertical stripes at an angular velocity of 0.85°/sec. Vestibular nystagmus was induced by horizontal rotation at an angular velocity of 30°/sec and caloric nystagmus by infusion of cold water into the external meatus. Cumulative injection of ethanol into the auricular vein to doses of 0.1, 0.2, 0.4 and 0.8 g/kg inhibited both vestibular and caloric nystagmus dosedependently, but did not affect the optokinetic nystagmus. These results suggest that relatively low doses of ethanol mainly act on the peripheral vestibular organ and impair the vestibular function without affecting the optokinetic system.
- 公益社団法人 日本薬理学会の論文
著者
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SASA Masashi
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hi
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Matsui Yoshie
Department Of Ophthalmology Kyoto Katsura Hospital
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Honda Yoshihito
Department Of Ophthalmology And Visual Science Graduate School Of Medicine Kyoto University
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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Kashii Satoshi
Department Of Ophthalmology And Visual Sciences Graduate School Of Medicine Kyoto University
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SASA Masashi
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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TAKAORI Shuji
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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KASHII Satoshi
Departments of Ophthalmology, Faculty of Medicine, Kyoto University,
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MATSUI Yoshie
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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HONDA Yoshihito
Departments of Ophthalmology, Faculty of Medicine, Kyoto University,
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