Relationships between Urinary Levels of Ulinastatin and .ALPHA.1-Microglobulin and the Severity of Alzheimer-Type or Vascular Dementia.
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概要
- 論文の詳細を見る
Ulinastatin (urinary trypsin inhibitor) and α<SUB>1</SUB>-microglobulin levels in urine samples of 39 dementia patients (Alzheimer-type dementia, 21 cases; vascular dementia, 18 cases) and 14 normal subjects were measured. There was a positive correlation between the ulinastatin and α<SUB>1</SUB>-microglobulin levels. Lower scores on the dementia rating scale and activities of daily living were observed in patients with Alzheimer-type dementia but not with vascular dementia, where a lower α<SUB>1</SUB>-microglobulin level was registered. However, the ulinastatin level did not correlate with the scores in patients with either Alzheimer-type or vascular dementia. These results indicate that the urinary ar-microglobulin level provides a useful biochemical index of the severity of Alzheimer-type dementia.
- 一般社団法人 日本臨床薬理学会の論文
著者
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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ISHINO Hiroshi
Department of Psychiatry, Shimane Medical University
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Ishino Hiroshi
Department Of Electrical And Electronic Engineering Toyohashi University Of Technology
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Hattori Keisuke
Department Of Cardiovascular Surgery Gifu Prefectural Tajimi Hospital
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SHIKIMP Tadahiro
Department of Pharmacology, Shimane Medical University
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HIMENO Yasutoshi
Department of Urology, Shimane Medical University
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ISHIBE Tomoyuki
Department of Urology, Shimane Medical University
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