Nitroarginine inhibits endothelium-derived relaxation.
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概要
- 論文の詳細を見る
Effects of N<SUP>G</SUP>-nitro-L-arginine (NO <SUB>2</SUB>Arg), a guanidinonitro arginine derivative, on acetylcholineinduced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO<SUB>2</SUB>Arg dose-dependently and the maximum relaxation with 10 μM NO<SUB>2</SUB> Arg was reduced to 10.1±4.3% (n=5). L-arginine (10 μM) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO<SUB>2</SUB>Arg. These results indicate that NO2Arg is a novel inFiibitor of endothelium-derived relaxation.
- 公益社団法人 日本薬理学会の論文
著者
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Hattori Keisuke
Department Of Cardiovascular Surgery Gifu Prefectural Tajimi Hospital
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Kobayashi Yuta
Department Of Experimental Animals Center For Integrated Research In Science Shimane University
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