LIPO-MICRODIALYSIS : A NEW MICRODIALYSIS METHOD FOR STUDYING THE PHARMACOKINETICS OF LIPOPHILIC SUBSTANCES
スポンサーリンク
概要
- 論文の詳細を見る
A new microdialysis method (Lipo-MD) using a lipid emulsion as the perfusate instead of Ringer's solution as in conventional microdialysis (MD) was designed. Recovery profiles of the alkylparabens (APBs) dissolved in Ringer's solution by Lipo-MD were compared with those by MD in vitro. Recovery of APBs in the perfusate in MD decreased with the increasing lipophilicity of APBs, whereas that in Lipo-MD increased. The enhancement of the relative recovery of APBs by Lipo-MD to MD for methyl-, ethyl-, propyl-, and butylparaben were 2.03,5.24,77.0,and 390.7,respectively. The utility of Lipo-MD for determination of lipophilic substances to perform pharmacokinetic study was suggested.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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Nakamura Shinya
Department of Molecular and Functional Genomics, Center for Integrated Research in Science, Shimane
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KAWASAKI Hiromu
Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceut
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Kawasaki Hiromu
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Okayama University
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KUROSAKI Yuji
Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Ok
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Okayama University
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Kawasaki Hiromu
Department Of Clinical And Pharmaceutical Science Graduate School Of Medicine Dentistry And Pharmace
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Kurosaki Yuji
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Graduate School Of
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Nakamura Shinya
Department Of Molecular And Functional Genomics Center For Integrated Research In Science Shimane Un
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SHIOJIRI Yoko
Department of Clinical Pharmaceutical Science, Faculty of Pharmaceutical Sciences, Okayama Universit
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Shiojiri Yoko
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Okayama University
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Nakamura Shinya
Department Of Clinical Pharmaceutical Science Faculty Of Pharmaceutical Sciences Okayama University
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Nakamura Shinya
Department Of Chemistry University Of Tsukuba
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