Changes in monoamine contents in the brains of Mongolian gerbils following a 5-min occlusion of the bilateral carotid arteries.
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概要
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Changes in cerebral monoamine metabolism were investigated in gerbils following a 5-min ischemia. During ischemia, monoamines were not changed, and 3-methoxy tyramine increased remarkably. After re-circulation, noradrenaline and serotonin decreased, and 5-hydroxyindole-3-acetic acid increased. Dopamine was not significantly changed: but its metabolites were elevated. At 1, 3 and 7 days after the ischemia, monoamine metabolism did not change. We discussed the possibility that these monoamine metabolism changes in the early period of reflow might be related to the delayed neuronal damage.
- 公益社団法人 日本薬理学会の論文
著者
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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KARASAWA Yasuko
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co. Ltd.
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AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co. Ltd.
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UCHIYAMA-TSUYUKI Yoshimi
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
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AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharamceutical Co., Ltd.
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KARASAWA Yasuko
Department of Pharmacology, Research Center, Taisho Pharmaceutical Co., Ltd.
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