Effect of chronic administration of antidepressants on duration of immobility in rats forced to swim.
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概要
- 論文の詳細を見る
Chronic administration of imipramine and desipramine significantly reduced the duration of immobility in rats forced to swim in comparison with acute administration. However, amitriptyline did not potentiate the reductive effect of chronic administration. Chlorimipramine, a selective serotonin uptake inhibitor, did not affect the duration of immobility in both the acute and chronic administration. On the other hand, the chronic administration of chlorpromazine, haloperidol and diazepam enhanced the duration of immobility, whereas their acute administration had no effect on it. Sulpiride reduced and enhanced the duration of immobility by the acute and chronic administration, respectively. The present results suggest that the chronic administration of drugs to rats in a forced swimming test can clarify the characteristics of the psychotropic drugs.
- 公益社団法人 日本薬理学会の論文
著者
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Araki Hiroaki
Department Of Clinical Pharmacology And Pharmacy Brain Science Ehime University Graduate School Of M
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KAWASHIMA Kazuaki
Department of Pharmacology, Research Center, Taisho Pharamceutical Co., Ltd.
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AIHARA Hironaka
Department of Pharmacology, Research Center, Taisho Pharamceutical Co., Ltd.
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