Correlation between Cyclosporine Blood Concentration-Dose Ratio and Biochemical Parameters in Living-Donor Lung Transplant Patients
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概要
- 論文の詳細を見る
Lung transplantation has proved to be an effective treatment worldwide for a variety of end-stage lung diseases. In Japan, living-donor lung transplantation is the predominant procedure used. In this and other types of transplantation, the calcineurin inhibitor cyclosporine (CYA) is frequently used as an immunosuppressive drug. However, this drug requires strict control of dosing to minimize the risk of rejection and over-imrnunosuppression, and for the orally administered drug, interand intra-individual bioavailability vary widely. Intensive drug monitoring is therefore necessary. In this study, 25 patients who received lung allografts from living donors between October 1998 and January 2006 at Okayama University Hospital were investigated to see if there was any correlation between the CYA concentration-dose ratio and biochemical parameters. The most significant correlation was between the CYA concentration-dose ratio and total cholesterol, with a correlation coefficient of 0.46. As for individual results in this respect, 14 of 25 patients had a correlation coefficient of 0.5 or greater, and the highest was 0.92. There was thus a definite correlation between the CYA concentration-dose ratio and total cholesterol in patients who had undergone living-donor lung transplantation.
- 日本医療薬学会の論文
- 2008-04-10
著者
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Sendo Toshiaki
Department Of Hospital Pharmacy Okayama University Medical And Dental School
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石井 雅人
姫路赤十字病院薬剤部
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Date Hiroshi
Department of Thoracic Surgery, Kyoto University
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Sendo Toshiaki
Department Of Hospital Pharmacy Faculty Of Medicine Kyushu University
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HIGAKI Kazutaka
Department of Basic Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
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KIMURA Toshikiro
Department of Pharmaceutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
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Sendo Toshiaki
Department Of Pharmacy Okayama University Hospital
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Ishii Masato
Department of Pharmacy, Okayama University Hospital
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Kawakami Yasuhiro
Department of Pharmacy, Okayama University Hospital
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Date Hiroshi
Departments Of Cancer And Thoracic Surgery Okayama University Graduate School Of Medicine Dentistry
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Kimura Toshikiro
Departments Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And
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Kimura Toshikiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Kawakami Yasuhiro
Department Of Pharmacy Okayama University Hospital
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Higaki Kazutaka
Departments Of Pharmaceutical Sciences Okayama University Graduate School Of Medicine Dentistry And
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Date Hiroshi
Department Of Cancer And Thoracic Surgery Field Of Patho-physiology Okayama University Graduate Scho
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Ishii Masato
Department Of Pharmacy Okayama University Hospital:departments Of Pharmaceutical Sciences Okayama Un
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Sendo Toshiaki
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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