Design of Controlled-Release Morphine Suppositories Containing Polyglycerol Ester of Fatty Acid(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Controlled-release morphine suppositories were prepared by utilizing polyglycerol ester of fatty acid (PGEF). The addition of PGEF to fatty suppository base Witepsol H15 resulted in a decrease of morphine release rate from suppositories. Among PGEFs examined, decaglycerol heptabehenate (HB750) was the most effective additive for the controlled-release of morphine from fatty suppositories. The apparent viscosity of suppository bases increased with the increase in HB750 content, and good correlation was observed between the apparent viscosity of suppository bases at 37℃ and the amount of HB750 added in the mixed base. The in vitro release rate of morphine was decreased by the addition of HB750 and the release rate constant (Higuchi's rate constant) for morphine release was significantly correlated with the HB750 content in the mixed bases as well as the apparent viscosity of mixed bases, indicating that the release of morphine from the mixed bases could be regulated by the HB750 content in the mixed bases. After rectal administration of Witepsol H-15-HB750 mixed suppositories to dogs, plasma concentrations of morphine did not increase rapidly at early time periods, but relatively high levels of morphine in plasma were sustained for longer time periods. Mean residence time of morphine was considerably prolonged without changing relative bioavailability in the case of the mixed base suppositories containing 15-17% HB750, compared with the Witepsol H15 suppository, clearly indicating that the mixed bases containing HB750 are expected to be useful for the design of controlled-release morphine suppositories.
- 公益社団法人日本薬学会の論文
- 2005-08-01
著者
-
HIGAKI Kazutaka
Department of Basic Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyoto University
-
KIMURA Toshikiro
Department of Pharmaceutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu
-
Takatori Toshihito
Pharmaceutical Technology Section Manufacturing Technology & Engineering Dainippon Pharmaceutica
-
Kimura Toshikiro
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
-
YAMAMOTO Kazumitsu
Pharmaceutical Research & Technology Center, Dainippon Pharmaceutical Co., Ltd.
-
YAMAGUCHI Toshikazu
Pharmaceutical Research & Technology Center, Dainippon Pharmaceutical Co., Ltd.
-
Higaki Kazutaka
Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Sci.
-
Yamamoto Kazumitsu
Pharmaceutical Research & Technology Center Dainippon Pharmaceutical Co. Ltd.
-
Yamaguchi Toshikazu
Pharmaceutical Research & Technology Center Dainippon Pharmaceutical Co. Ltd.
関連論文
- Effect of Medium-Chain Glycerides on the Membrane Transport of D-Glucose and Sulfanilic Acid in the Intestinal Brush-Border Membrane Vesicles
- EFFECT OF MEDIUM-CHAIN GLYCERIDES (MGK^[○!R]) ON THE INTESTINAL ABSORPTION AND THE HEPATOBILIARY TRANSPORT OF BROMTHYMOL BLUE
- Interaction of Polyphenols with Proteins : Binding of (-)-Epigallocatechin Gallate to Serum Albumin, Estimated by Induced Circular Dichroism
- Correlation between Cyclosporine Blood Concentration-Dose Ratio and Biochemical Parameters in Living-Donor Lung Transplant Patients
- ANTIGEN-INDUCED DECREASE OF SALICYLIC ACID ABSORPTION FROM THE SMALL INTESTINE IN ACTIVELY IMMUNIZED RATS
- High-performance liquid chromatographic determination of diadenosine 5',5'''-p^1,p^4-tetraphosphate with precolumn fluorescence derivatization and its application to metabolism study in whole blood
- Optimization of Suppository Preparation Containing Sodium Laurate and Taurine That Can Safely Improve Rectal Absorption of Rebamipide(Biopharmacy)
- Interaction of Polyphenolic Metabolites with Human Serum Albumin: A Circular Dichroism Study
- Evaluation of Poly(vinyl alcohol)-Gel Spheres Containing Chitosan as Dosage Form to Control Gastrointestinal Transit Time of Drugs
- Design of Controlled-Release Morphine Suppositories Containing Polyglycerol Ester of Fatty Acid(Biopharmacy)
- Usefulness of Liposomes as an Intranasal Dosage Formulation for Topical Drug Application
- Analysis and Prediction of Absorption Behavior for Theophylline Orally Administered as Powders Based on Gasrtointestinal-transit-Absorption (Gita) Model
- DESIGN AND SYNTHESIS OF COLON-SPECIFIC PRO-ANTEDRUGS, 20-GLUCOPYRANOSYLOXY METHYLPREDNISOLONATES, FOR ORAL TREATMENT OF ULCERATIVE COLITIS AND THEIR METABOLISM
- RECENT TRENDS IN GASTROINTESTINAL DELIVERY OF PEPTIDES
- In Vitro Evaluation of Nasal Mucociliary Clearance Using Excised Rat Nasal Septum
- Development of Transdermal Therapeutic Formulation of CNS5161, a Novel N-Methyl-D-aspartate Receptor Antagonist, by Utilizing Pressure-Sensitive Adhesives I
- In Vitro Evaluation of the Ciliary Beat Frequency of the Rat Nasal Epithelium Using a High-Speed Digital Imaging System
- Nanoparticle-Based Passive Drug Targeting to Tumors: Considerations and Implications for Optimization
- S24. Continuous Production of Nanoemulsion Using a Microfluidic Device with Ultrasonic Vibration(Oral Presentation)
- Regulation of Drug Absorption from Small Intestine by Enteric Nervous System I : a Poorly Absorbable Drug Via Passive Diffusion