Clinical Significance of Hepatocyte Growth Factor and Its Specific Receptor c-Met Expression in Colorectal Cancer Progression

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概要

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• To clarify the clinical significance of hepatocyte growth factor (HGF) and its specific receptor c-Met in colorectal cancer, we performed serological analysis of HGF in 108 patients who underwent colon cancer surgery and 200 agematched control subjects, and immunohistochemical analysis of HGF and c-Met in surgically resected samples in 50 of the 108 patients. Serological analysis demonstrated that preoperative serum HGF level was significantly higher in the cancer group than in the control group (p<0.0001), and increased in patients with advance of depth of invasion (p=0.0173), liver metastasis (p=0.0024), and tumor stage (p=0.0069). Immunohistochemical analysis demonstrated the strong expression and colocalization of HGF and c-Met in the cancer cells. Tissue HGF staining score was increased in patients with advance of venous invasion (p=0.0092), whereas tissue c-Met staining score was decreased in patients with advance of lymphatic invasion (p=0.0234), liver metastasis (p=0.0176), and serum HGF level over 300 pg/mL (p=0.018). The present results suggest that the verification of both preoperative serum HGF level and tissue HGF and c-Met levels contributes to the prognostic evaluation of tumor progression in the preoperative period. Furthermore, it is likely that HGF oversupply-associated c-Met downregulation occurs in colorectal cancer via autocrine, paracrine and endocrine mechanisms.

• 日本組織細胞化学会の論文

著者

• Shibata Noriyuki

  Department of Pathology, Tokyo Women’s Medical University

• Kobayashi Makio

  Department of Pathology, Tokyo Women’s Medical University

• SAITO NOBORU

  Department of Cardiology, Tenri Hospital

• Shibata Noriyuki

  Dept. Of Pathology Tokyo Women's Medical University

• Shibata Noriyuki

  Department Of Pathology Tokyo Women's Medical College

• Sakayori Noriko

  Department Of Pathology Tokyo Women's Medical University

• KAMEOKA Shingo

  Department of Surgery II, School of Medicine Tokyo Women's Medical University

• Kawaguchi Motoko

  Department Of Surgical Pathology Tokyo Women's Medical University

• Kobayashi M

  Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School

• Kobayashi Masatoshi

  Department Of Anatomy & Histology Kurume University School Of Medicine

• Kobayashi Makio

  Department Of Pathology Tokyo Women's Medical College

• Kobayashi Makio

  Dept. Of Pathology Tokyo Women's Medical University

• Kobayashi Makio

  東京女子医科大学 消化器内科学

• Saito N

  Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro

• Hashimoto Takuzo

  Department of Surgery II, Tokyo Women's Medical University

• Hashimoto T

  Department Of Surgery Omiya Central General Hospital

• Kobayashi M

  Departments Of Pathology Tokyo Women

• Kameoka Shingo

  Department Of Surgery Ii Tokyo Women's Medical University

• Kameoka Shingo

  Department Of Surgery 2 Tokyo Women's Medical University

• Kameoka Shingo

  Department Of Surgery Ii Tokyo Women's Mecical University School Of Medicene

• Kobayashi Minatsu

  Department Of Public Health Social Medicine And Medical Informatics Ehime University Graduate School

• Kameoka S

  Department Of Surgery Ii Tokyo Women's Medical University

• Kobayashi Minatsu

  Epidemiology And Prevention Division Research Center For Cancer Prevention And Screening National Ca

• Kobayashi M

  Aska Pharmaceutical Co. Ltd. Research & Development Division

• Kobayashi Makio

  Department Of Immunology And Pathology Yamanashi Medical College

• Hashimoto Tsuyoshi

  Department Of Radiology Tokyo Medical University Kasumigaura Hospital

• Saito Noboru

  Department Of Surgery Ii Tokyo Women's Mecical University School Of Medicene

• Saito Noboru

  Department Of Applied Chemistry And Molecular Science Faculty Of Engineering Iwate University

• Shibata Noriyuki

  Department Of Pathology School Of Medicine Tokyo Women's Medical University

• Hashimoto Takuzo

  Department Of Surgery Ii Tokyo Women's Medical University

• Kobayashi Makio

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

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