Hemoconcentrating Substance and Vascular Permeability Factor from Rat Kidney Lysosomes : Possible Involvement of Lysosomes in the Pathogenesis of Cardiovascular Diseases

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Rats kidneys were subjected to subcellular fractionation according to SHIBKO and TAPPEL and 0.9 per cent saline extracts of four subcellular fractions were assayed for vasoactive principles. Two different vasoactive principles have been detected in lysosomal extract in highest concentration. One is the hemoconcentrating substance (HCS) which induces transitory hyper-erythrocythemia and hyperproteinemia by systemic administration. It is heat labile and antihistamine refractory. Another is the vascular permeability factor which provokes protein bound dye leakage by intradermal injection. It is heat stable and suppressed by antihistamine. It is suggested that hemoconcentration is induced by ultrafiltration in capillary beds due to increased hydrostatic pressure in consequence of venular constriction. The results of the present study are compatible with the assumption that HCS is renin, as well as the vascular permeability factor is the Permeability Increasing Factor. Possible involvement of kidney lysosomes in the pathogenesis of cardiovascular diseases including essential hypertension and congestive heart failure is discussed.
社団法人日本循環器学会の論文
1968-02-20