COLUMN CHROMATOGRAPHIC ANALYSIS OF RELATOINSHIP BETWEEN HYPERTENSION-INDUCING POTENCY AND RENIN CONTENT OF KIDNEY EXTRACT
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between hypertension-inducing potency and renin content of kidney extract was analyzed in rats using Sephadex G-100, CM-Sephadex C-50, DEAE-Cellulose or Concanavalin A-Sepharose column chromatography. Hypertension-inducing potency of each fraction obtained was evaluated on the basis of the final blood pressure level attained by repeated injections into the test animals for 10 days. Hypertension-inducing potency was found mainly in the renin-containing fractions. And it seems reasonable to conclude that renin is implicated in the pathogenesis of hypertension produced by kidney extract. However, there were significant discrepancies between hypertension-inducing potency and renin content of subdivided fractions of these renin-containing eluates. Possible explanations for the discrepancies disclosed-including the possibility of the involvement of an unknown substance(s)-have been discussed. In addition, it was suggested from the result of Concanavalin A-Sepharose chromatography that rat renal renin has a glycoprotein nature.
- 社団法人日本循環器学会の論文
- 1976-02-20
著者
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Kawai Chuichi
The 3rd Division Dept. Of Intern. Med. Kyoto University School Of Medicine And Osaka Medical College
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OGINO KOICHI
National Cardiovascular Center, Research Institute
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Kira Jun
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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OGINO KOICHI
The 3rd Medical Clinic, Kyoto University Hospital, Kyoto
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YAMAMOTO JIN
The 3rd Division, Department of lnternal Medicine, Faculty of Medicine, Kyoto University
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MATSUNAGA MASATO
The 3rd Department of lnternal Medicine, Faculty of Medicine, Kyoto University
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MATSUNAGA Masato
Kyoto Univ.
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Yamamoto Jin
National Cardiovascular Center Researchinstitute
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Yamamoto Jin
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ogino Koichi
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Yamamoto Jin
National Himeji Hosp. Dept. Of Intern. Med
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Ogino Koichi
Third Division Department Of Internal Medicine
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Ogino Koichi
3rd Dept. Of Intern. Med. Kyoto Univ.
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Ogino Koichi
3rd Division Dept. Of Intern. Med. Kyoto Univ. Sch. Of Med.
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Matsunaga Masato
Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology
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Matsunaga Masato
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Yamamoto Jin
Third Division Department Of Internal Medicine
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Ogino Koichi
The 3rd Medical Clinic Kyoto University Hospital Kyoto
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Kawai C
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Kawai Chuichi
The 3rd Department Of Internal Medicine Kyoto University School Of Medicine
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Kira Jun
Department Of Internal Medicine National Himeji Hospital
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Kira Jun
Dept. Of Intern. Med. National Himeji Hosp.
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Kira Jun
3rd Div. Dept. Of Intern. Med. (prof. M. Maekawa) Facul. Of Med. Kyoto University Kyoto
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Ogino Koichi
3rd Div. Dept. Of Intern. Med. School Of Med. Kyoto Univ.
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Matsunaga Masato
Central Clinical Laboratories Kyoto Univ. Hosp.
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