Experimental Coxsackie Virus B-3 and B-4 Myocarditis in Mice : Proceedings of the II. Conference on Prevention for Rheumatic Fever and Rheumatic Heart Disease
スポンサーリンク
概要
- 論文の詳細を見る
Mice were inoculated with recently isolated Coxsackie virus B-3 and B-4 intraperitoneally. Severest lesions in the hearts were observed in mice between the age of 7 and 14 days. Grossly, yellow-white patches were seen on the hearts of mice from the 7th day to the 6th month after virus inoculation. Microscopically, the hearts showed extensive myocardial necrosis, inflammation with small mononuclear cells and calcification on the day of 7. There were myocardial fibrosis and calcification at the 6th month after inoculation with Coxsackie virus B-3, and at the 3rd month after inoculation with Coxsackie virus B-4, but generally pathologic changes were less severe in the latter. Myocardial fibrosis in the present experiment was most prominent among the experiments we have studied. It was confirmed that chronic myocardial fibrosis follows acute Coxsackie virus myocarditis in mice. Possible role of Coxsackie virus myocarditis in the development of cardiomyopathy was briefly discussed.
- 社団法人日本循環器学会の論文
- 1978-02-20
著者
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Matsumori Akira
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Kawai Chuichi
The 3rd Division Dept. Of Intern. Med. Kyoto University School Of Medicine And Osaka Medical College
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Kawai Chuichi
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kumagai Naoie
Department of cardiology, Shiga Medical Center for adult diseases
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Kawai Chuichi
The 3rd Department Of Internal Medicine Kyoto University School Of Medicine
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Kumagai Naoie
Department Of Cardiology Shiga Medical Center For Adult Diseases
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Kumagai Naoie
Department Of Internal Medicine Faculty Of Medicine Kyoto University
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TOKUDA Masao
Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Tokuda Masao
Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
Department Of Cardiology Kyoto University
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