EXOGENOUS COENZYME Q ATTENUATES THE TENSION PROLONGATION PHENOMENON
スポンサーリンク
概要
- 論文の詳細を見る
In order to determine whether exogenous coenzyme Q can modify the course of mechanical changes in the myocardium during hypoxia and reoxygenation, we studied isolated rat heart muscles contracting isometrically at Lmax, 12 times per minutes at 28℃. The prehypoxic mechanical parameters of 6 control muscles and 6 muscles treated with coenzyme Q10 (40mμg/ml in the bath) did not differ, nor did the changes in developed tension and resting tension during 15min of hypoxia and 45 min of reoxygenation. However, the time it took for the tension to fall to 50% of the peak value (RT_< 1/2 >), the time from the onset of contraction to peak isometric tension (TPT) and TPT+RT_< 1/2 > on early reoxygenaion were significantly diminished in coenzyme Q treated muscles. Thus, the tension prolongation phenomenon was attenuated in preparations of coenzyme Q treated rat heart muscle. It is concluded from this study that exogenous coenzyme Q does not modify the mechanical performance of isolated rat heart muscle during hypoxia but significantly attenuates the tension prolongation pjenomenon. Since oxygen free radicals are known to induce mitochondrial dysfunction and impairment of calcium sequestration in the sacroplasmic reticulum, the mechanism by which coenzyme Q attenuates the tension prolongation phenomenon is probably attributable to its function as an antioxidant.
- 社団法人日本循環器学会の論文
- 1984-01-20
著者
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Kawai Chuichi
The 3rd Division Dept. Of Intern. Med. Kyoto University School Of Medicine And Osaka Medical College
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Konishi Tomotsugu
The 3rd Div., Dept, of Intern. Med., Fuculty of Med., Kyoto Univ.
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KONISHI Takashi
The Third Division, Department of Internal Medicine. Faculty of Medicine, Kyoto University
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NAKAMURA YASUYUKI
The 3rd Division, Department of Internal Medicine Faculty of Medicine, Kyoto University
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Konishi T
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Nakamura Yasuyuki
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Kawai Chuichi
The 3rd Department Of Internal Medicine Kyoto University School Of Medicine
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Nakamura Y
Second Department Of Internal Medicine Kyoto Prefectural University Of Medicine
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Nakamura Yasuyuki
The 3rd Division Dept. Of Internal Medicine Faculty Of Medicine Kyoto University And Beth Israel Hos
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