KINETIC ANALYSES OF CREATINE KINASE RELEASE PATTERNS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION UNDERGOING EMERGENCY CORONARY ARTERIOGRAPHY

概要

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To quantify the of early reperfusion on the size of infarcts, an enzyme indicator was developed: myocardial creatine kinese (CK) release tare (K_r),based on a compartment kinetics model. In 59 patients with acute myocardial infraction (MI) who received intracoronary thrombolysis therapy in the acute phase, the K_r showed a good correlation with the flow condition of infarct-related coronary artery and the time required to reach peak enzyme activity. Apparent serum CK disappearance rate (K_d') was estimated by using the method of Norris. The k_d' was significantly underestimated in patients without reperfusion, suggesting the presence of prolonged enzyme release from the infarcted area. In 22 of 59 patients, who had a first acute anterior MI(left anterior descending arterial lesion), the correction of cumulative enzyme release by myocardial enzyme release (K_r) resulted in a closer correlation with chronic phase left ventricular function. Thus, kinetic analysed of serum enzyme release provide a useful means to estimate the infarct size during intracoronary thrombolysis therapy.
社団法人日本循環器学会の論文
1990-05-20