Viral Myocarditis: Immunopathogenesis and the Effect of Immunosuppressive Treatment in a Murine Model : SYMPOSIUM ON SEVERAL ASPECTS OF MYOCARDITIS
スポンサーリンク
概要
- 論文の詳細を見る
Serial changes in lymphocyte subset were investigated in an animal model of encephalomyocarditis (EMC) virus myocarditis in mice. The lymphocyte subset in the peripheral blood was measured by flow cytometry and, T cell subset in the myocardium was stained by labeled avidin-biotin technique. Helper-inducer T cells (Lyt 1 cells) decreased significantly on day 7, but there was no change in cytotoxic-suppressor T cells in the peripheral blood. During the acute stage a significant number of T cells (Thy 1.2 cells) were seen in the heart with helper-inducer T cells precominating. The effect of prednisolone and cyclosporine on viral myocarditis was studied in our experimental model. Prednisolone or cyclosporine given in the early stage aggravated the course, and they did not have beneficial effects during the early recovery period.
- 社団法人日本循環器学会の論文
- 1989-01-20
著者
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Matsumori Akira
同志社大学 生命医科学部
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KAWAI CHUICHI
The Third Division, Department of lnternal Medicine, Kyoto University Hospital
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MATSUMORI AKIRA
The Third Department of Internal Medicine
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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TOMIOKA NOBUYOSHI
The Third Division,Department oflnternal Medicine,Kyoto University
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Tomioka Nobuyoshi
The Third Division Department Oflnternal Medicine Kyoto University
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Tomioka Nobuyoshi
Third Div. Int. Med. Kyoto Univ. Central Clin. Lab. Kyoto Univ. Hosp.
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Kawai Chuichi
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
Department Of Cardiology Kyoto University
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