Pathogenesis and Preventive and Therapeutic Trials in An Animal Model of Dilated Cardiomyopathy induced by A Virus : SYMPOSIUM ON CURRENT STATUS OF DILATED CARDIOMYOPATHY : 50th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
An animal model of dilated cardiomyopathy following encephalomyocarditis (EMC) virus has been developed. Virus was isolated from mouse hearts and viral antigens were detected in the myocardium until the second week of infection, but neither was found thereafter. Differences were found among different strains of mice in the frequency of occurrence and severity of myocarditis, and even in the character of the pathologic lesions. Thus, genetic factors may play an important role in the pathogenesis. Autoantibodies against heart developed and the distribution of cardiac myosin isoenzymes was altered during the course of myocarditis. Virus, vaccine, maternal vaccination, recombinant interferon alpha A/D and ribavirin were effective in protecting the mice from developing myocarditis. This animal model is suitable for studying the pathogenesis of viral myocarditis and evaluating preventive and therapeutic interventions of the condition.
- 社団法人日本循環器学会の論文
- 1987-06-20
著者
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MATSUMORI AKIRA
The Third Department of Internal Medicine
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Miura Aya
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Abelmann W
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Kawai Chuichi
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Matsumori Akira
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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CRUMPACKER CLYDE
Department of Medicine, Beth Israel Hospital, Harvard Medical School
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ABELMANN WALTER
Department of Medicine, Beth Israel Hospital, Harvard Medical School
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Matsumori A
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Kawai C
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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Kawai Chuichi
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Crumpacker Clyde
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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