Acid Angiotensinase as a Lysosomal Enzyme
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概要
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1. Both acid angiotensinase and calcium-dependent neutral angiotensinase are widely distributed among various tissues of the rat. High activity of acid angiotensinase in such lysosome-rich tissues as kidney, spleen and liver suggests localization of this enzyme in lysosomes. 2. Main angiotensinases in rat liver are concentrated in lysosomal and soluble fractions. The lysosomal enzyme which is inhibited by DFP is acid angiotensinase, while the other is calcium-dependent neutral angiotensinase. 3. The pH optimum of lysosomal angiotensinase of the kidney is 5.6-5.7. Properties of acid angiotensinase indicate that a carboxypeptidase, so-called angiotensinase C, is a lysosomal eazyme and plays a main role in lysosomal angiotensinase activity. On the other hand, partial inhibition and activation by p-chloromercuribenzoate and dithiothreitol imply that some other enzyme(s) may take part in this activity. 4. Acid angiotensinase of kidney lysosomes was separated from arylamidase and hemoglobin-splitting cathepsin by Sephadex gel-filtration. Cathepsin A activity, however. Could not be eliminated from the acid angiotensinase by either Sephadex gel-filtration or DEAE-cellulose Column chromatography. DFP showed an inhibitory effect on cathepsin A activity of kidney lysosomes. 5. Molecular weight of lysosomal acid angiotensinase of rat kidney is between 70,000 and 90.000, calculated by Sephadex gel-filtration. 6. Possible role of the lysosomal enzyme in angiotensin metabolism in vivo is discussed.
- 社団法人日本循環器学会の論文
- 1969-08-20
著者
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Kira Jun
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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SAITO NOBORU
Clinical Nutrition Laboratory, Kyoto University Hospital
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OGINO KOICHI
Third Division, Department of Internal Medicine
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MATSUNAGA Masato
Kyoto Univ.
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Ogino Koichi
The Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ogino Koichi
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Takayasu Masao
The 3rd Medical Clinic Faculty Of Medicine Kyoto University
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Takayasu Masao
Kyoto Medical Association For Prevention Of Cardiovascular Disease Kyoto National Hospital
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Takayasu Masao
3rd Div. Dept Of Intern. Med. & 2nd Div. Dept Of Surg. Kyoto Univ. Faculty Of Med.
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Takayasu Masao
3rd Dept. Of Intern. Med. Kyoto Univ.
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MATSUNAGA MASATO
Division of Internal Medicine, School of Medicine, Kyoto University
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SAITO NOBORU
Division of Internal Medicine, School of Medicine, Kyoto University
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KIRA JUN
Division of Internal Medicine, School of Medicine, Kyoto University
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OGICHI KOICHI
Division of Internal Medicine, School of Medicine, Kyoto University
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TAKAYASU MASAO
Division of Internal Medicine, School of Medicine, Kyoto University
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Matsunaga Masato
Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology
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Matsunaga Masato
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ogino Koichi
Maekatva Clinic Kyoto University Hospital
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Saito Noboru
Clinical Nutrition Laboratory Kyoto University Hospital
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Kira Jun
Department Of Internal Medicine National Himeji Hospital
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Kira Jun
Dept. Of Intern. Med. National Himeji Hosp.
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Takayasu Masao
Department Of Internal. Medicine Kyoto University School Of Medicine
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Kira Jun
3rd Div. Dept. Of Intern. Med. (prof. M. Maekawa) Facul. Of Med. Kyoto University Kyoto
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Takayasu Masao
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
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Takayasu Masao
3rd Dept. Of Intern. Med. Facul Of Med. Kyoto Univ.
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Matsunaga Masato
Central Clinical Laboratories Kyoto Univ. Hosp.
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Saito Noboru
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
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