Analysis of Relationship Between Renin-Angiotensin System and Blood Pressure in Experimental Hypertension Induced by Kidney Extract (3 Conference of Pathogenesis of Hypertension<特集>)
スポンサーリンク
概要
- 論文の詳細を見る
Kidney extract (I), (II) and (III) were obtained from rats which were adrenalectomized and given tap water, adrenalectomized and given 10 g/l NaCl, and intact, respectively. When each extract was subcutaneously injected every 12 hours into uninephrectomized rats, the blood pressure was gradually elevated. This hypertension-inducing action was observed more or less in every extracts. The potency was (I) > (II) > (III) while no apparent disparity was found in renin content of the three extracts. During and after the development of hypertension, plasma renin level was not increased 12 hours after the injection except in the recipients of extract (I), even in the presence of a high blood pressure. However, from an aspect of changes following each individual injection, the effect of the kidney extract on the plasma renin level appeared to be parallel with its hypertension-inducing effect. The latter effect, therefore, could be attributed to a cumulative effect of an excessive fluctuation of the renin-angiotensin level or the blood pressure, although implication of other renal substances than renin would not be excluded. Continuous high level of plasma renin or angiotensin may accelerate the development of hypertension.
- 社団法人日本循環器学会の論文
- 1975-01-20
著者
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OGINO KOICHI
National Cardiovascular Center, Research Institute
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Kira Jun
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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OGINO KOICHI
The 3rd Medical Clinic, Kyoto University Hospital, Kyoto
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YAMAMOTO JIN
The 3rd Division, Department of lnternal Medicine, Faculty of Medicine, Kyoto University
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MATSUNAGA MASATO
The 3rd Department of lnternal Medicine, Faculty of Medicine, Kyoto University
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MATSUNAGA Masato
Kyoto Univ.
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Yamamoto Jin
National Cardiovascular Center Researchinstitute
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Yamamoto Jin
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ogino Koichi
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Yamamoto Jin
National Himeji Hosp. Dept. Of Intern. Med
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Ogino Koichi
Third Division Department Of Internal Medicine
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Ogino Koichi
3rd Dept. Of Intern. Med. Kyoto Univ.
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Ogino Koichi
3rd Division Dept. Of Intern. Med. Kyoto Univ. Sch. Of Med.
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Matsunaga Masato
Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology
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Matsunaga Masato
The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Yamamoto Jin
Third Division Department Of Internal Medicine
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Ogino Koichi
The 3rd Medical Clinic Kyoto University Hospital Kyoto
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Kira Jun
Department Of Internal Medicine National Himeji Hospital
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Kira Jun
Dept. Of Intern. Med. National Himeji Hosp.
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Kira Jun
3rd Div. Dept. Of Intern. Med. (prof. M. Maekawa) Facul. Of Med. Kyoto University Kyoto
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Ogino Koichi
3rd Div. Dept. Of Intern. Med. School Of Med. Kyoto Univ.
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Matsunaga Masato
Central Clinical Laboratories Kyoto Univ. Hosp.
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