ROLE OF RENIN-ANGIOTENSIN SYSTEM IN EXPERIMENTAL HYPERTENSION IN RATS : Plasma Renin and Hypotensive Effect of Angiotensin II Antagonist

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概要

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• The hypotensive effect of 1-Sar-8-Ile-angiotensin II, a competitive antagonist of angiotensin II, and the pre-infusion level of plasma renin concentration were examined in conscious rats with various types of hypertension to assess the role of the renin-angiotensin system in the pathogenesis of experimental hypertension. The infusion of 1-Sar-8-Ile-A II (0.64 μg/min or 3.2 μg/min) caused a significant fall in blood pressure in two-kidney Goldblatt rate (4-5 weeks after clipping) and 7-8-month-old stroke-prone spontaneously hypertensive rats (SHR), while it was statistically ineffective in one-kidney Goldblatt rats (4-5 weeks after clipping), one- and two-kidney Loomis rats (2 and 4-5 weeks after induction), 5-month-old stroke-prone SHR and 2-, 5-, 8- and 14-month-old stroke-resistant SHR. A significant correlation between plasma renin concentration and the susceptibility to the antagonist was observed in Goldblatt rats and stroke-prone SHR, but not in Loomis rats and stroke-resistant SHR. Some groups of animals which had not responded to the original infusion of 1-Sar-8-Ole-A II were infused again with the same antagonist in a furosemide-induced volume-depleted state, in which plasma renin level was prominently elevated in all rats and angiotensin-II dependency of blood pressure was disclosed except in the 8-month-old stroke-resistant SHR. These data suggest that the renin-angiotensin system is critically involved in the two-kidney Goldblatt rats and the 7-8-month-old stroke-prone SHR, but that it is much less important in other hypertensive rats and other factors would be involved especially in case of stroke-resistant SHR.

• 社団法人日本循環器学会の論文
• 1977-07-20

著者

• YAMAMOTO JIN

  The 3rd Division, Department of lnternal Medicine, Faculty of Medicine, Kyoto University

• Yamamoto Jin

  The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

関連論文

• Plasma Renin and the Antihypertensive Effect of Angiotensin-II Antagonist in Experimental Hypertension
• Plasma Renin and Vascula Complications in Substrains of the Spontaneously Hypertensive Rat, with a Reference to Water and Electrolyte Balance
• PLASMA RENIN AND HYPERTENSIVE VASCULAR COMPLICATIONS : AN OBSERVATION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT
• Hypertensive Vascular Lesions and Renin or Lysosomal Enzymes in Rats
• HEMODYNAMIC EFFECTS OF BETA-ADRENERGIC BLOCKADE IN HYPERTENSION : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
• COLUMN CHROMATOGRAPHIC ANALYSIS OF RELATOINSHIP BETWEEN HYPERTENSION-INDUCING POTENCY AND RENIN CONTENT OF KIDNEY EXTRACT
• Analysis of Relationship Between Renin-Angiotensin System and Blood Pressure in Experimental Hypertension Induced by Kidney Extract (3 Conference of Pathogenesis of Hypertension)
• ROLE OF RENIN-ANGIOTENSIN SYSTEM IN EXPERIMENTAL HYPERTENSION IN RATS : Plasma Renin and Hypotensive Effect of Angiotensin II Antagonist

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