Lysosomal Enzyme Activities in Rat Kidney treated with DOCA, especially with Reference to Renin, Cathepsin and β-Glucuronidase
スポンサーリンク
概要
- 論文の詳細を見る
In the cytoplasmic fraction (C. F.) of rats treated with DOCA plus salt, renal renin activity was already decreased before the development of hypertension and was more suppressed after that of hypertension. Renal cathepsin activity was slightly increased shortly before the development of hypertension and more elevated after that of hypertension. Increased renal β-glucuronidase activity was found after the longer duration of hypertension. Deoxyribonuclease activity was slightly increased in average after the development of hypertension, but not significantly. Ribonuclease and β-glycerophosphatese activities were not increased, rather slightly decreased after the development of hypertension. The percentage of soluble fraction (S1) or supernatant fraction (S2) to cytoplasmic fraction (C. F.) was diminished in both cathepsin and β-glucuronidase activities in rats treated with DOCA plus high salt as compared with that in the controls, but was nearly identical with that in the controls in β-glycerophosphatase activity. The probable role of lysosomal acid hydrolases in hypertensive vascular lesions was discussed.
- 社団法人日本循環器学会の論文
- 1973-12-20
著者
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Takayasu Masao
Cardiovascular(CV) Reseach and Training Center of Alabama Univ. School of Med.
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Takayasu Masao
The 3rd Dept. of Med. Clinic., Kyoto Univ. Hosp.
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TAKAYASU MASAO
The National Kyoto Hosp
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SAITO NOBORU
Clinical Nutrition Laboratory, Kyoto University Hospital
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OGINO KOICHI
Third Division, Department of Internal Medicine
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OGINO KOICHI
The 3rd Medical Clinic, Kyoto University Hospital, Kyoto
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MUKAINO SAKAE
Clinical Nutrition Laboratory, Faculty of Medicine, Kyoto University
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Ogino Koichi
The Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ogino Koichi
The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University
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Takayasu Masao
The 3rd Medical Clinic Faculty Of Medicine Kyoto University
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Matsuda Takayuki
The National Kyoto Hosp
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Takayasu Masao
3rd Div. Dept Of Intern. Med. & 2nd Div. Dept Of Surg. Kyoto Univ. Faculty Of Med.
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Takayasu Masao
3rd Dept. Of Intern. Med. Kyoto Univ.
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Ogino Koichi
Third Division Department Of Internal Medicine
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Ogino Koichi
Maekatva Clinic Kyoto University Hospital
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Saito Noboru
Clinical Nutrition Laboratory Kyoto University Hospital
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Takayasu Masao
Department Of Internal. Medicine Kyoto University School Of Medicine
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Mukaino Sakae
Clinical Nutrition Laboratory Faculty Of Medicine Kyoto University
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Takayasu Masao
Third Dept. Of Intern. Med. Facul. Of Med. Univ. Of Kyoto
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Takayasu Masao
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
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Saito Noboru
Clinical Nutrition Laboratory School Of Medicine Kyoto University
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Saito Noboru
Clinical Nutrition Laboratory Kyoto Univ. Hosp.
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MUKAINO Sakae
Clinical Nutrition Laboratory
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SAITO Noboru
Clinical Nutrition Laboratory and Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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