The Relationship between Periarteritis Nodosa and Blood Pressure in Stroke-prone Spontaneously Hypertensive Rats
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概要
- 論文の詳細を見る
The bead-like lesion in rat mesenteric artery occurred more frequent in old stroke-prone spontaneously hypertensive rats(SHRSP), aged over 8 months, and especially in male SHRSP than in female SHRSP or in older SHRSP than in old SHRSP, while it was very rare in older stroke-resistant SHH(SHRSR) and was not found in older Wistar Kyoto rats(WKY). The bead-like lesion was periarteritis nodosa microscopically. Electronmicroscopically, various cells such as endothelial cells, fibroblast-like cells and leucocytes showed the activated states; the well-developed Golgi apparatus and the dilated lumens of rough endoplasmic reticulum. In SHRSP of both sexes, aged 12-19.5 months, systolic blood pressure was higher in the cases with bead-like lesion than in the cases without it, and this finding was confirmed by the increment of heart weight. Therefore, high blood pressure is one factor to induce bead-like lesion in mesenteric artery.
- International Heart Journal刊行会の論文
著者
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Nishiyama Shoji
Department Of Environmental Health Kochi Medical School
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Saito Noboru
Department Of Applied Chemistry And Molecular Science Faculty Of Engineering Iwate University
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Okada Teruhiko
Department Of Anatomy And Cell Biology Kochi Medical School
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Okada Teruhiko
Department of Geriatrics, Kochi Medical University
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Nishiyama Shoji
Department of Environmental and Occupational Health, Kochi Medical University
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Nishiyama Shoji
Department of Geriatrics, Kochi Medical University
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