EFFECTS OF RES-BLOCKADE ON IMMUNE RESPONSE. : I. THE EFFECTS OF COLLOIDAL CARBON INJECTION ON THE PRIMARY ANTI-SRBC ANTIBODY AND DELAYED HYPERSENSITIVITY RESPONSES
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概要
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The role of the reticuloendothelial system (RES) in the immune response was studied in mice. Mice were first injected i.v. with colloidal carbon and then stimulated with sheep erythrocytes (SRBC) through the same route at various time intervals. The immune response was modified when the RES-blocked mice were stimulated with SRBC either at the same time as with carbon or 1-3 days later. The splenic direct and indirect plaque-forming cells (DPFC and IPFC) responses and the serum antibody responses were suppressed in RES-blocked mice stimulated with a high dose of SRBC one day after carbon treatment. In contrast, these responses were enhanced in RES-blocked mice stimulated with a low dose of SRBC. The induction of delayed hypersensitivity against intravenous sensitization with SRBC was inhibited in RES-blocked mice one day after carbon treatment.
- 日本組織細胞化学会の論文
著者
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Okada Teruhiko
Department Of Anatomy And Cell Biology Kochi University Faculty Of Medicine
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Okada Teruhiko
Department Of Anatomy Kyoto University Faculty Of Medicine
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Okada Teruhiko
Department Of Anatomy And Cell Biology Kochi Medical School
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