Chronological Expression and its Significance of c-jun and c-fos mRNA in Rat Brain

スポンサーリンク

概要

• 論文の詳細を見る

• We investigated the expression of c-jun and c-fos proto-oncogenes and their distribution in the brain of newborn to adult rats to determine the relationship between proto-oncogene expression and brain development, by the reverse transcription-polymgrase chain rection (RT-PCR) method, in situ hybridization and immunohistochemistry. In the RT-PCR analysis, the cDNA fragments of c-jun and c-fos were amplified with expected-sizes, and the expression levels were fixed through all ages examined. The in situ hybridization showed that the expression of c-jun and c-fos mRNA was located at the cytoplasm of most neurons and some glial cells of the entire portions of the cerebrum, brainstem and cereberum until 300 days after birth. c-Jun protein immunoreactivity was detected in the nucleus of neurons which demonstrated a positive signal by in situ hybridization. Our results suggest that even after neuroblasts differentiate to mature neurons, c-jun and c-fos genes may have a role in the preservation of the neuronal function of the rat central nervous system.

著者

• Kato Yasuko

  Department Of Anatomy Yamanashi Medical University

• Kato Yuzuru

  Department Of Medicine Shimane Medical University

• Kato Y

  Department Of Pathology Tokyo Women's Medical University

• Shibata Noriyuki

  Department Of Pathology Tokyo Women's Medical University

• Shibata Noriyuki

  Dept. Of Pathology Tokyo Women's Medical University

• Shibata Noriyuki

  Department Of Pathology Tokyo Women's Medical College

• Sakayori Noriko

  Department Of Pathology Tokyo Women's Medical University

• Kato Yoichiro

  Department Of Pathology Tokyo Women's Medical University

• Kobayashi Masatoshi

  Department Of Anatomy & Histology Kurume University School Of Medicine

• Kobayashi Makio

  Department Of Pathology Tokyo Women's Medical College

• Kobayashi Makio

  Dept. Of Pathology Tokyo Women's Medical University

• Saito N

  Department Of Molecular And Pharmacological Neuroscience Graduate School Of Biomedical Sciences Hiro

• Kobayashi M

  Departments Of Pathology Tokyo Women

• Sawada T

  Department Of Pathology Tokyo Women's Medical University

• Sawada Tatsuo

  Department Of Mechanical Engineering Keio University

• Kobayashi M

  Aska Pharmaceutical Co. Ltd. Research & Development Division

• Kobayashi Makio

  Department Of Immunology And Pathology Yamanashi Medical College

• Sawada Tatsuo

  Department Of Pathology Tokyo Women's Medical College

• Shibata Noriyuki

  Department Of Pathology School Of Medicine Tokyo Women's Medical University

• Kobayashi Makio

  Department of Agricultural Chemistry, Faculty of Agriculture, Hokkaido University

関連論文

• F-3 Living Salmonella administration induces an acute reduction in wheel-running activity via TLR5 but not TLR4 in mice(Free communication (Slide),8^ INTERNATIONAL SOCIETY OF EXERCISE AND IMMUNOLOGY SYMPOSIUM,ISEI2007 INFLAMMATION IN EXERCISE FRIEND O
• Late Progression After Sirolimus-Eluting Stent Implantation for de Novo Lesions : Comparison With Bare Metal Stent Implantation
• Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo
• Seasonal Variation of Trace Element Loss to Sweat during Exercise in Males
• Concentrations of Trace Elements in Sweat during Sauna Bathing
• Recombinant Human Interleukin-11 Decreases Severity of Acute Necrotizing Pancreatitis in Mice
• Intrahepatic biliary epithelial cell damage and inflammation in portal tract in association with chronic colitis-harboring TCRα^ mice
• A case of malignant pheochromocytoma
• Biliary Tract Involvement in Autoimmune Pancreatitis
• Digestion and Gastrointestinal Absorption of the 14-16-kDa Rice Allergens
• QUANTITATIVE ULTRASTRUCTURAL CHANGES IN RAT PROLACTIN CELLS : RELATIONSHIP TO THE REBOUND IN SERUM PROLACTIN LEVELS AFTER BROMOCRIPTINE TREATMENT
• SENSITIVE IMMUNOHISTOCHEMICAL DEMONSTRATION OF ENDOGENOUS PROLACTIN IN MAMMARY GLAND AND DMBA-INDUCED MAMMARY CARCINOMA OF RATS BY ABC METHOD
• Immunohistochemical Study of Obliterated Arteriovenous Malformations after Gamma Knife Radiosurgery
• Degradation of Soluble Proteins Including Some Allergens in Brown Rice Grains by Endogenous Proteolytic Activity during Germination and Heat-Processing
• Surgical Stress Increases Renal Glutathione Content via Increased Glucocorticoid, and Resistance to Subsequent Oxidative Injury in the Rat: Significant Link Between Endocrine Response and Cell Defense System under the Stress
• Pathological Finding of Sirolimus-Eluting Stent (SES) Restenosis Lesion With Black Hole Appearance on Intravascular Ultrasound
• OE-015 Impact of Chronic Kidney Disease and Diabetes on Long-Term Prognosis in Patients with Primary Angioplasty for Acute Coronary Syndrome(Acute coronary syndrome, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of
• INVERSE CORRELATION BETWEEN THYROID PEROXIDASE (TPO) AND GAMMA-GLUTAMYL TRANSPEPTIDASE (GGT) ACTIVITIES EXPRESSED IN DIISOPROPANOLNITROSAMINE (DIPN) INDUCED RAT THYROID LESIONS : AN ENZYME HISTOCHEMICAL STUDY
• Immunohistochemical localization of tubulin in ischemic retina of grebils
• Effects of the PPARγ activator pioglitazone on p38 MAP kinase and IκBα in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis
• Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model
• Intracellular binding of fukutin and α-dystroglycan : Relation to glycosylation of α-dystroglycan
• WS1-3 Accumulation of protein-bound crotonaldehyde in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
• Clinicopathological study on eyes from cases of Fukuyama type congenital muscular dystrophy
• Unique astrocytic inclusion in a 2 month-old baby showing Leigh-like brain lesions with lactic acidosis
• P-39 Continuous expression of c-jun and c-fos oncogene in developmental stage of rat brain
• Early stage of human adenovirus type 12-inoculated retinal tissue of F344 newborn rat
• Embryological Fusion Between the Ducts of the Ventral and Dorsal Primordia of the Pancreas Occurs in Two Manners
• Expression of Thyroid Transcription Factor-1(TTF-1)in Human C Cells and Medullary Thyroid Carcinomas
• Gene Expression of type II and type X Collagen in Endochondral Ossification
• Pial-glial barrier abnormalities in fetuses with Fukuyama congenital muscular dystrophy
• Fukuyama congenital muscular dystrophy: Cortical dysplasia of the cerebrum in a 20 week fetus
• Vibration analysis of obturator prostheses with different bulb height designs
• Prevalence of herpesviridae and hepatitis virus sequences in the livers of patients with fulminant hepatitis of unknown etiology in Japan
• F-22 The different effects of exhaustive exercise on poly I:C-induced IFN-β and TNF-α productions in mice(Free communication (Slide),8^ INTERNATIONAL SOCIETY OF EXERCISE AND IMMUNOLOGY SYMPOSIUM,ISEI2007 INFLAMMATION IN EXERCISE FRIEND OR FOE?)
• Expression of Vascular Endothelial Growth Factor (VEGF) and Specific Receptors (Flt-1 and Flk-1) in Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
• Immunohistochemical Localization of Copper-Zinc and Manganese Superoxide Dismutases in Human Tissues
• Immunohistochemical localization of superoxide dismutase (SOD) in the background lesions of diisopropanolnitrosamine (DIPN) induced rat thyroid tumor
• The alteration of retinal superoxide dismutase(SOD) in streptozotocin(STZ)-induced diabetic rats : Immunohistochemical study
• IMMUNOHISTOCHEMICAL LOCALIZATION OF COPPER-ZINC AND MANGANESE SUPEROXIDE DISMUTASES IN RAT TISSUES
• Demonstration of neuropil thread-like structures in the spinal cord white matter in progressive supranuclear palsy: An immunohistochemical investigation
• Spatiotemporal Analysis of the Molecular Interaction between PICK1 and PKC
• Clinical Significance of Hepatocyte Growth Factor and Its Specific Receptor c-Met Expression in Colorectal Cancer Progression
• P2-08 Visualization of intracellular signaling system : immunogold electron microscopic study on γPKC translocation
• Immunogold electron microscopic studies on stimulus-specific γ PKC translocation-a Synergistic effect of Ca^ phorbol ester on PKC translocation
• A-1 Immunogold electron microscopic studies of subtype- and stimulus-specific PKC translocation
• Osteopontin Expression May Be Induced by c-Src in Papillary Thyroid Carcinoma
• Osteopontin Expression in Papillary Thyroid Carcinoma
• A-35 Electron microscopic replica immunostaining analysis of splenic AA amyloid fibrils in serum amyloid P (SAP) component-deficient mice
• Immunohistochemical Study of Splenic Amyloid Deposits in Serum Amyloid P Component(SAP)-deficient Mice.
• Dystrobrevin localization in various ocular tissues and cerebellum of rats revealed by immunoelectron microscopy
• Scanning electron microscopic study of erythrocyte shapes artificially jetted through tubes at different pressures by 'in vitro cryotechnique for erythrocytes'
• Scanning electron microscopic study of flowing erythrocytes in hepatic sinusoids as revealed by 'in vivo cryotechnique'
• An Endothelial Nitric Oxide Synthase Inhibitor Aggravates CDL-Induced Acute Pancreatitis in Rats
• Clinicopathological Factors Influencing the Apparent Diffusion Coefficients Obtained by Diffusion-weighted Magnetic Resonance Imaging in Patients with Colorectal Cancer
• Inhibition of hepatic metastasis in mice treated with cell-binding domain of human fibronectin and angiogenesis inhibitor TNP-470
• Primary mucosa-associated lymphoid tissue-type lymphoma arising in the kidney
• Molecular biological approaches to neurological disorders including knockout and transgenic mouse models
• Demonstration and distribution of tau-positive glial coiled body-like structures in white matter and white matter threads in early onset Alzheimer's disease
• Small-bowel hemorrhage caused by cytomegalovirus vasculitis following fulminant hepatitis
• Apoptosis in metastatic carcinoma of the central nervous system
• Activation of the Non-receptor Tyrosine Kinase cSrc in Macrophage-rich Atherosclerotic Plaques of Human Carotid Arteries
• Antivascular effects of TZT-1027 (Soblidotin) on murine Colon26 adenocarcinoma
• Glyoxal inactivates glutamate transporter-1 in cultured rat astrocytes
• Pathological and immunohistochemical findings of an autopsy case of adult moyamoya disease
• The Distribution of Pur Alpha Protein in Rat Tissues, and Its Intracellular Location
• Pur α Protein Implicated in Dendritic RNA Transport Interacts with Ribosomes in Neurosal Cytoplasm
• A-40 Retinal opsin mRNA in situ hybridization in the monkey retina.
• Immunohistochemical Detection of Retinal Cones in Monkey Retina : Light and Electron Microscopic Study
• Morphological Aspects of Superoxide Dismutase-1 Mutation in Amyotrophic Lateral Sclerosis and its Transgenic Mouse Model (Symposium VIIHistochemistry for Neuroscience Research)
• Growth and Astaxanthin Formation of Haematococcus pluvialis in Heterotrophic and Mixotrophic Conditions
• TZT-1027, an Antimicrotubule Agent, Attacks Tumor Vasculature and Induces Tumor Cell Death
• Induction of Apoptosis in Mice with B16 Melanoma by Treatment with the Antimicrotubule Agent TZT-1027
• Antitumor Activity of TZT-1027, a Novel Dolastatin 10 Derivative
• Comparison of inhibitory effects of warfarin on γ-carboxylation between bone and liver in rats
• Effects of Vitamin K_2 (Menatetrenone) on Calcium Balance in Ovariectomized Rats
• Inhibitory Effect of Vitamin K_2 (Menatetrenone) on Bone Resorption in Ovariectomized Rats : A Histomorphometric and Dual Energy X-Ray Absorptiometric Study
• A Case of Contact Urticaria from Hydroxypropyltrimonium Hydrolyzed Collagen
• Demonstration of neurofibrillary tangles in the indusium griseum and of axonal disturbances in sagittal sulcal lesions of the corpus callosum: An immunohistochemical investigation
• Occipital Lobe Ependymal Cyst
• Primary Leiomyosarcoma of the Breast Treated by Partial Resection of the Breast Including Nipple and Areola : Report of a Case
• Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
• Fukutin expression in mouse non-muscle somatic organs : its relationship to the hypoglycosylation of α-dystroglycan in Fukuyama-type congenital muscular dystrophy
• I-B-11 Localization of Monocarboxylate Transporters MCT1 and MCT4 in Rat Skeletal Muscle (2^ report)(THE 45TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
• B-16 A morphological investigation of the relationship between arachnoid membrane and the core of arachnoid granulations by 5^1-nucleotidase histochemistry
• Characterization of the Interaction of TZT-1027, a Potent Antitumor Agent,with Tubulin
• RAPID PURIFICATION OF MONOCLONAL ANTIBODY IN ASCITES BY HIGH PERFORMANCE ION EXCHANGE COLUMN CHROMATOGRAPHY FOR DIMINISHING NON-SPECIFIC STAINING
• Chronological Expression and its Significance of c-jun and c-fos mRNA in Rat Brain
• Argyrophilic meshwork structures in the cerebral cortex of patients with progressive supranuclear palsy
• Plaque-like structures in the cerebral cortex of corticobasal degeneration : A histopathologic marker?
• Ovomucoid Rendered Insoluble by Heating with Wheat Gluten but not with Milk Casein
• Effects of the Glycoprotein Sugar Chains on the Amino-Carbonyl Reaction of Chicken and Japanese Quail Ovomucoids With Glucose
• A Preliminary Report on Investigations at Institutions for the Elderly in Shanghai, China and Okayama, Japan : What is Becoming Old?
• A Novel and Simple Method of Insolubilization of Ovomucoid in Cookies Prepared from Batter Containing Egg White
• Familial amyotrophic lateral sclerosis and Cu/Zn superoxide dismutase mutation
• Expression of Osteopontin in Thyroid Tumors
• Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
• New insights into the pathogenesis of spinal muscular atrophy
• Serum Integrin β1 Levels as a Prognostic Marker in Metastatic Colorectal Cancer
• Bovine serum albumin coordinated iron-sulfur cluster as a hydrogenase model.

もっと見る 閉じる

スポンサーリンク