Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
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概要
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The effects of ω-5 gliadin on wheat-dependent exercise-induced anaphylaxis (WDEIA) were investigated by using a mouse model. The gliadin fraction was prepared as a 70% ethanol-soluble solution, and ω-5 gliadin was purified by chromatography. Purified ω-5 gliadin was run on SDS–PAGE gel to reveal three bands with a molecular mass of 53–60 kDa and had the characteristic N-terminal sequence of ω-5 gliadin. The mice were sensitized to the gliadin fraction, and the anaphylactic response was assessed by measuring the body temperature and voluntary physical activity. An oral administration of ω-5 gliadin evoked a significant drop in both the body temperature and voluntary physical activity, similar to the effects of the whole gliadin fraction. ELISA and immunoblotting analyses revealed that the IgE expression from sensitized mice reacted most strongly to ω-5 gliadin. Taken together, these results indicate ω-5 gliadin to be a major allergen responsible for stimulating WDEIA in mice, with the characteristic potential for stimulating IgE production.
- 2011-02-23
著者
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TANAKA Mamoru
Department of Electrical and Electronics Engineering, Sophia University
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Kato Yasuko
Department of Clinical Nutrition, Kawasaki University of Medical Welfare
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NAGANO Takao
Department of Clinical Nutrition, Kawasaki University of Medical Welfare
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YANO Hiromi
Department of Health and Sports Science, Kawasaki University of Medical Welfare
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IKEDA Tatsuya
National Agricultural Research Center for Western Region
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Haruma Ken
Division Of Gastroenterology Department Of Internal Medicine Kawasaki Medical School
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Kato Yasuko
Department Of Anatomy Yamanashi Medical University
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Kato Yasuko
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
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Kato Yasuko
Graduate School Of Medical Professions Kawasaki University Of Medical Welfare
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Yano Hiromi
Department Of Health & Sports Science Kawasaki University Of Medical Welfare
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Matsuda Tsukasa
Department Of Applied Biological Sciences School Of Agricultural Sciences Nagoya University
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Yano Hiromi
Department Of Health And Sports Science Kawasaki University Of Medical Welfare
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Nagano Takao
Department Of Chemistry Faculty Of Textile Science And Technology Shinshu University
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Matsuda Tsukasa
Graduate School Of Applied Molecular Bioagricultural Sciences Nagoya University
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Ikeda Tatsuya
National Agricultural Res. Center For Western Region National Agriculture And Food Organization
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Tanaka Mamoru
Department Of Electrical And Electronics Engineering Sophia University
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Matsuda Tsukasa
Department Of Applied Biological Science School Of Agricultural Science Nagoya University
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Nagano Takao
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
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Yano Hiromi
Department Of Cardiovascular Surgery Hachioji Medical Center Of Tokyo Medical University
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Tanaka Mamoru
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
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Tanaka Mamoru
Department Of Applied Chemistry Kobe City College Of Technology
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