Mechanism of A23187-Induced Apoptosis in HL-60 Cells : Dependency on Mitochondrial Permeability Transition but Not on NADPH Oxidase
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概要
- 論文の詳細を見る
Calcium ions (Ca2+) are involved in a number of physiological cellular functions including apoptosis. An elevation in intracellular levels of Ca2+ in A23187-treated HL-60 cells was associated with the generation of both intracellular and extracellular reactive oxygen species (ROS) and induction of apoptotic cell death. A23187-induced apoptosis was prevented by cyclosporin A, a potent inhibitor of mitochondrial permeability transition (MPT). The generation of extracellular ROS was suppressed by the NADPH oxidase inhibitor diphenylene iodonium, and by superoxide dismutase, but these agents had no effect on A23187-induced apoptosis. In contrast, the blocking of intracellular ROS by a cell-permeant antioxidant diminished completely the induction of MPT and apoptosis. In isolated mitochondria, the addition of Ca2+ induced a typical MPT concomitant with the generation of ROS, which leads to augmentation of intracellular ROS levels. These results indicate that intracellular not extracellular ROS generated by A23187 is associated with the opening of MPT pores that leads to apoptotic cell death.
- 社団法人 日本農芸化学会の論文
- 2007-11-23
著者
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YANO Hiromi
Department of Health and Sports Science, Kawasaki University of Medical Welfare
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Yano Hiromi
Department Of Health & Sports Science Kawasaki University Of Medical Welfare
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Utsumi Kozo
Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and
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Utsumi K
Department Of Cytology And Histology Okayama University Graduate School Of Medicine Dentistry And Ph
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Utsumi Kozo
Department Of Biochemistry Cancer Institute Okayama University Medical School
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YASUDA Tatsuji
Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry
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Yasuda Tatsuji
Dep. Of Cell Chemistry Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Yasuda Tatsuji
Department Of Cell Chemistry Institute Of Cellular And Molecular Biology Okayama University Medical
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Utsumi Kozo
Department Of Cytology And Histology Okayama University Graduate School Of Medicine Dentistry And Ph
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Utsumi Kozo
Dep. Of Cytology And Histology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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KOBUCHI Hirotsugu
Department of Cell Chemistry, Institute of Cellular and Molecular Biology, Okayama University Medica
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Yoshioka T
Kurashiki Medical Center Kurashiki Jpn
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Fujita Hirofumi
Department Of Cytology And Histology Okayama University Graduate School Of Medicine Dentistry And Ph
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KAJITANI Noriko
Department of Cell Chemistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmac
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FUJIWARA Takuzo
Department of Surgery, Tsuyama Central Hospital
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Fujiwara Takuzo
Department Of Surgery Tsuyama Central Hospital
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Kajitani Noriko
Department Of Cell Chemistry Okayama University Graduate School Of Medicine Dentistry And Pharmaceut
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Yano Hiromi
Department Of Cardiovascular Surgery Hachioji Medical Center Of Tokyo Medical University
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Kobuchi Hirotsugu
Department Of Cell Chemistry Okayama University Graduate School Of Medicine Dentistry And Pharmaceut
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Yasuda Tatsuji
Department Of Cell Chemistry Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Okayama University
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