INTERACTION OF TETRACHLOROBIPHENYLS WITH ISOLATED RAT LIVER MITOCHONDRIA
スポンサーリンク
概要
- 論文の詳細を見る
A comparative study of the effects of tetrachlorobiphenyls (TCBs) on the succinate-supported respirations of rat liver mitochondria was made, and some differences in effects caused by the different chlorine positions of the biphenyl rings were clarified. The inhibitory actions of 2,3,2', 3'-, 2,4,2', 4'-, and 2,5,2', 5'-TCBs on both state 3 and uncouplerstimulated respirations were potent, while those induced by 2,6,2', 6'-, and 3,4,3', 4'-TCBs were weak. 2,3,2', 3'-, 2,4,2', 4'-, 2,5,2', 5'-, and 2,6,2', 6'-TCBs stimulated state 4 respiration, but 3,4,3', 4'-TCB had very little effect on this respiration. The latent adenosine triphosphatase activity was stimulated by 2,3,2', 3'-, 2,4,2', 4'-, and 2,5,2', 5'-TCBs, but 2,6,2', 6'-, and 3,4,3', 4'-TCBs had no effects. The relationship between these effects and chemical structure of TCBs is discussed.
- 公益社団法人日本薬学会の論文
著者
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Utsumi Kozo
Department of Cytology and Histology, Okayama University Graduate School of Medicine, Dentistry and
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Utsumi K
Kochi Medical School Kochi Jpn
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Utsumi Kozo
Department Of Biochemistry Cancer Institute Okayama University Medical School
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OESCH FRANZ
Institute of Pharmacology, University of Mainz
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Utsumi Kozo
Dep. Of Cytology And Histology Okayama Univ. Graduate School Of Medicine Dentistry And Pharmaceutica
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Oesch Franz
Institut Fur Toxikologie Universitat Mainz
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NISHIHARA YOSHIMASA
Department of Medical Biology, Kochi Medical School
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