THE EFFECTS OF ECHINATIN AND ITS RELATED COMPOUNDS ON THE MITOCHONDRIAL ENERGY TRANSFER REACTION
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the mechanism by which various biological action of licorice root are brought about, the effects of echinatin as a small constituent of Glycyrrhiza echinata and several related compounds on mitochondrial energy transfer reactions were examined. The results obtained were as follows: 1) Echinatin, 4'-hydroxychalcone, chalcone and 3,4'-dihydroxychalcone at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria. 2) Chalcone and 4'-hydroxychalcone stimulate both latent and DNP-ATPase activity of mitochondria. Echinatin inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. 3) Chalcone and 4'-hydroxychalcone induce a rapid potassium release from mitochondrial vesicles, while echinatin and 3,4'-dihydroxychalcone have lesser effect than the former two substances. From these results, it can be concluded that echinatin and several related compounds disturb the mitochondrial energy transfer reactions and membrane permeability.
- 日本トキシコロジー学会の論文
- 1982-11-25
著者
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Utsumi Kozo
Department Of Medical Biology Kochi Medical School
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Utsumi Kozo
Department Of Biochemistry Cancer Institute Okayama University Medical School
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井上 豊治
岡山県環境保健センター
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Mori Takaaki
岡山県環境保健センター
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INABA Kozo
Department of Cell Biology, Hyogo University of Teacher Education
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IZUSHI Fumio
岡山県環境保健センター
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ETO Kohei
岡山県環境保健センター
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SAKAI Ritsue
岡山県環境保健センター
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OGATA Masana
岡山県環境保健センター
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Inaba Kozo
Department Of Cell Biology Hyogo University Of Teacher Education
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