POTENTIATION OF ISOPROTERENOL-INDUCED SALIVATION BY LABETALOL

スポンサーリンク

概要

• 論文の詳細を見る

• The authors previously reported that low doses of labetalol potentiated isoproterenol (ISO)-induced salivation in mice. The present study was carried out to ascertain the potentiating effect of labetalol in in vitro experiments using rat parotid tissue slices and their isolated cells. ISO-induced amylase release was enhanced by low concentrations of labetalol (less than 10<SUP>-6</SUP> M), while it was inhibited by high doses (more than 10<SUP>-5</SUP> M). This potentiating effect of labetalol did not occur in the Ca-free medium used for incubation or in experiments using the dispersed parotid cells or the parotid tissues which were obtained from 6-hydroxydopamine or reserpine-treated rats. The effect of ISO on cyclic AMP accumulation in parotid tissue was completely blocked by the addition of labetalol in concentrations which were sufficient to increase the ISOinduced amylase release. Labetalol also inhibited the ISO-induced reduction of potassium release in parotid tissue. From these results, it is concluded that increases in the secretion of amylase and potassium from salivary glands due to the stimulation of glandular α-adrenoceptors by endogenous norepinephrine may play an important role in the potentiating effect of labetalol on ISO-induced salivation in mice.

• 社団法人 日本薬理学会の論文

著者

• TANAKA Mamoru

  Department of Electrical and Electronics Engineering, Sophia University

• Ohshika Hideyo

  Department Of Pharmacology Sapporo Medical College

• TAKEMURA Haruo

  Department of Pharmacology, Sapporo Medical College

• ENDO Junichiro

  Department of Pharmacology, Sapporo Medical College

• Tanaka Mamoru

  Department Of Electrical And Electronics Engineering Sophia University

• Ohshika Hideyo

  札幌医科大学 薬理

• Tanaka Mamoru

  Department Of Applied Chemistry Kobe City College Of Technology

関連論文

• AS-3-5 Sigma-Delta Modulation by Cellular Neural Network
• Multi-Amplitude and Multi-Phase Synchronization Phenomena in Nonlinear Large-Scaled Oscillating Cellular Neural Networks
• Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma
• Phase-Inversion Waves in Oscillators Coupled by Two Kinds of Inductors as a Ladder(Nonlinear Theory and its Applications)
• Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
• Separable 2D Lifting Using Discrete-Time Cellular Neural Networks for Lossless Image Coding(Nonlinear Theory and its Applications)
• Numerical Analysis of Cellular Oscillating Networks based on Relaxation-based Method
• Maximum-Flow Neural Network : A Novel Neural Network for the Maximum Flow Problem
• H1foo is Indispensable for Meiotic Maturation of the Mouse Oocyte
• IS-47 The intraovarian ErbB system constitutes a family of heterogenously-regulated ligands of the epidermal growth factor : A possible role in the ovulatory process
• IS-61 Silencing of the human ovary-specific acidic protein gene suppresses steroid secretion by adrenocortical cells(Group8 Perinatology1,International Session)
• A-8. Traumatic Pneumocephalus
• CHANGES IN SALIVARY FUNCTIONS OF RAT PAROTID GLAND BY REPEATED ADMINISTRATION OF ISOPROTERENOL
• Evaluation of the Biodegradability of Polyurethane and Its Derivatives by Using Lipase-Displaying Arming Yeast
• S-C-4. A Study on the Treatment Cervical Syndrome
• Moyamoya-disease-related ischemic stroke in the postpartum period
• Occipital scalp hemangioma : Prenatal sonographic and magnetic resonance images
• P1-IS-78 Selective suppression of 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) gene expression by midkine, a heparin-binding growth factor, in human fetal adrenal cells
• P-IS-89 Role of midkine, a heparin-binding growth factor, in the development of the human fetal adrenal gland(Perinatology 5,Group 110,International Session)
• Chromatin Remodeling with Oocyte-specific Linker Histones
• 哺乳類における卵子特異的リンカーヒストン
• Hierarchical Least-Squares Algorithm for Macromodeling High-Speed Interconnects Characterized by Sampled Data
• Sparse Realization of Passive Reduced-Order Interconnect Models via PRIMA (VLSI Design Technology and CAD)
• Hysteresis Neural Networks for N-Queens Problems (Special Section on Nonlinear Theory and Its Applications)
• Impact of ω-5 Gliadin on Wheat-Dependent Exercise-Induced Anaphylaxis in Mice
• HEPATIC RESPONSES TO ADRENERGIC AND CHOLINERGIC STIMULATION IN CCl_4-TREATED RATS
• BINDING SITE OF OUABAIN IN CARDIAC MUSCLE CELL AND ITS POSITIVE INOTROPIC EFFECT IN CAT
• ACCUMULATION OF 3H-DIGITOXIN IN CNS OF CATS WITH A HYPERSENSITIVITY TO THE DRUG
• POTENTIATION OF ISOPROTERENOL-INDUCED SALIVATION BY LABETALOL
• A POSSIBLE ROLE OF ALPHA ADRENERGIC RECEPTORS IN SALIVATION INDUCED BY ISOPROTERENOL IN MICE
• STIMULATING EFFECT OF α-ADRENOCEPTOR AGONISTS ON ISOPROTERENOL-INDUCED AMYLASE RELEASE IN RAT PAROTID TISSUE
• Mitral Valve Thrombus Attached to the Intact Mitral Valve Associated With Distal Embolism
• Dreaming of fetal ICU
• Double mental foramina of the mandible on computed tomography images : a case report
• CARDIOVASCULAR TOLERANCE AND AUTONOMIC NERVOUS RESPONSES IN UNSEDATED UPPER GASTROINTESTINAL SMALL-CALIBER ENDOSCOPY : A COMPARISON BETWEEN TRANSNASAL AND PERORAL PROCEDURES WITH NEWLY DEVELOPED MOUTHPIECE
• INCREASE IN POTASSIUM RELEASE FROM RAT PAROTID TISSUE REPEATEDLY EXPOSED TO ISOPROTERENOL
• S-III-2. Shunting Prpcedure for Poor Risk Patients with Intracranial Aneurysm
• Beta cell dysfunction and its clinical significance in gestational diabetes
• Final diagnosis in patients with congenital cystic lung disease detected by fetal ultrasonography
• Congenitally corrected transposition of the great arteries
• The effect of omeprazole on gastric myoelectrical activity and emptying
• Nonlinear multi-agent path search method based on OFDM communication
• Abnormal first-trimester fetal nuchal translucency and amniotic band syndrome
• Retrospective evaluation of intravenous fentanyl patient-controlled analgesia during labor
• ISP-10-10 Platelet-activating factor is implicated in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat(Group 10 Perinatology-1,IS Poster,International Session)
• .BETA.1-Adrenoceptor-mediated amylase release and cyclic AMP accumulation in rat parotid gland tissue.
• Increase of .ALPHA.1-adrenoceptor binding after exposure to isoproterenol in rat parotid glands.
• .BETA.1-Adrenergic regulation of cyclic nucleotide levels and potassium fluxes in rat parotid gland.
• Isoproterenol inhibition of potassium release from rat parotid gland.
• Effects of repeated exposure to isoproterenol in vivo and in vitro on amylase release from rat parotid tissue.
• Alteration in Ca2+/Calmodulin-sensitive Adenylyl Cyclase Activity in the Hippocampus and the Cerebral Cortex of Stroke-prone Spontaneously Hypertensive Rats

もっと見る 閉じる

スポンサーリンク