STIMULATING EFFECT OF α-ADRENOCEPTOR AGONISTS ON ISOPROTERENOL-INDUCED AMYLASE RELEASE IN RAT PAROTID TISSUE
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概要
- 論文の詳細を見る
Isoproterenol (ISO)-induced amylase release from rat parotid slices was increased by the addition of methoxamine to either a normal or a calcium (Ca)-free medium. The potentiating effect of methoxamine was completely blocked by the addition of phentolamine, irrespective of whether the slices were incubated in the normal or the Ca-free medium; and the effect also disappeared after prolonged preincubation (60 min) of the slices in the Ca-free medium. Both verapamil and procaine reduced methoxamine-induced amylase release, but only verapamil blocked the stimulating effect of methoxamine in the normal medium. ISO-induced accumulation of cyclic AMP in the slices was unaffected by methoxamine or phenylephrine. The results suggest a possibility that the potentiating effect of methoxamine on ISO-induced amylase release may be independent of the presence of extracellular Ca and the increased accumulation of cyclic AMP in the tissue is unnecessary.
- 社団法人 日本薬理学会の論文
著者
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TANAKA Mamoru
Department of Electrical and Electronics Engineering, Sophia University
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Ohshika Hideyo
Dept. Of Pharmacology Sapporo Medical College
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Ohshika Hideyo
Department Of Pharmacology Sapporo Medical College
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Hatta Shinichi
Department Of Pharmacology Sapporo Medical College
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TAKEMURA Haruo
Department of Pharmacology, Sapporo Medical College
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ENDO Junichiro
Department of Pharmacology, Sapporo Medical College
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Tanaka Mamoru
Department Of Electrical And Electronics Engineering Sophia University
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Ohshika Hideyo
札幌医科大学 薬理
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Tanaka Mamoru
Department Of Applied Chemistry Kobe City College Of Technology
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