Isoproterenol inhibition of potassium release from rat parotid gland.
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概要
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The mechanism of isoproterenol-induced inhibition of potassium release from rat parotid slices has been determined. Spontaneous potassium release from the slices was significantly inhibited by isoproterenol at concentrations above 10<SUP>-6</SUP> M. This isoproterenol effect was completely abolished in the presence of propranolol (10<SUP>-5</SUP>M) and ouabain (10<SUP>-3</SUP> M) and was abolished during Na<SUP>+</SUP>-exclusion from the incubation medium. Isoproterenol caused an enhancement of the microsomal Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase activity at concentrations above 10<SUP>-5</SUP> M, and this activity was inhibited by propranolol (10<SUP>-5</SUP> M). The stimulatory effect of isoproterenol on the Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase exhibited a strong correlation with the inhibition of potassium release on each dose of isoproterenol. Moreover, dibutyryl cyclic AMP at concentrations above 10<SUP>-4</SUP> M inhibited potassium release in a dose-dependent manner and cyclic AMP caused an enhancement of the microsomal Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase activity. These results suggest that the inhibitory effect of isoproterenol on potassium release is clearly derived from the elevated Na<SUP>+</SUP>, K<SUP>+</SUP>-ATPase activity and that it may in part be mediated by cyclic AMP.
- 公益社団法人 日本薬理学会の論文
著者
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Miyamoto Atsushi
Department Of Cardiovascular Medicine School Of Medicine Hokkaido University
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Ohshika Hideyo
Department Of Pharmacology Sapporo Medical College
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OHSHIKA Hideyo
Department of Pharmacology, Sapporo Medical College
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