Endothelium-Dependent Relaxation in Response to Low Concentrations of Bradykinin Is Enhanced by Phosphoramidon, Bosentan and BQ-123 in Bovine Coronary Arteries In Vitro

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概要

• 論文の詳細を見る

• An endothelin (ET)-converting enzyme inhibitor phosphoramidon (10 μM), an ETAB-receptor antagonist bosentan (10 μM) and an ETA-receptor antagonist BQ-123 (1 μM) potentiated endothelium-dependent relaxation of bovine coronary arteries in response to bradykinin (BK) at femtomolar to picomolar concentrations, but not at nanomolar concentrations. BQ-788 (3 μM), an ETB-receptor antagonist, showed no significant effects on fM – nM BK-induced relaxation. These results suggest that the endothelium-dependent relaxation of isolated bovine coronary arteries induced by very low concentrations of BK is partly regulated by a complex mechanism involving the ETA-receptor antagonism.

• 2001-06-01

著者

• NAKAMURA Yutaka

  Department of Industrial and Systems Engineering, Setsunan University

• Nishio Akira

  Laboratory of Veterinary Pharmacology

• Miyamoto Atsushi

  Department Of Cardiovascular Medicine School Of Medicine Hokkaido University

• Miyamoto Atsushi

  Department Of Veterinary Pharmacology Faculty Of Agriculture Kagoshima University

• Nishio A

  Department Of Veterinary Pharmacology Faculty Of Agriculture Kagoshima University

• Nishio Akira

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University

• Ishiguro S

  Department Of Veterinary Pharmacology Faculty Of Agriculture Kagoshima University

• ISHIGURO Shigeru

  Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University

• KAWASE June

  Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University

• Kawase June

  Department Of Veterinary Pharmacology Faculty Of Agriculture Kagoshima University

• Nakamura Yutaka

  Department Of Animal Sciences Ibaraki University

• Nakamura Yutaka

  Department Of Veterinary Pharmacology Faculty Of Agriculture Kagoshima University

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