Vasomotor effect of histamine on pig and cattle coronary artery in vitro.
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概要
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Vasomotor effects of histamine were examined in isolated coronary arteries from pigs and cattle. Histamine produced a concentration-dependent contraction in these arteries. These contractile responses were dose-dependently inhibited by diphenhydramine. The slopes of the Schild plots, however, were significantly lower than unity in both species. Cimetidine potentiated the histamine-induced contractions at relatively high doses of histamine (larger than 10<SUP>-5</SUP> M) in pig coronary arteries, but did not show a significant effect in cattle arteries. After the removal of endothelium, the Schild plot of diphenhydramine against histamine gave a straight line with a pA<SUB>2</SUB> value of 7.80 and slope of 1.00 in pigs, confirming the competitive nature of the antagonism. In cattle, the slope was significantly lower than unity; however, in the presence of cimetidine, it was not significantly different from unity. Dimaprit did not contract the cattle coronary arteries with endothelium, but contracted them after the removal of endothelium. These results suggest that histamine-induced vasoconstriction in pig and cattle coronary arteries is mainly dependent on the H<SUB>1</SUB>-receptors in the smooth muscle cells, and that H<SUB>1</SUB>- and H<SUB>2</SUB>-receptors in the endothelial cells of pigs and H<SUB>2</SUB>-receptors in the smooth muscle cells of cattle modify the histamine-induced vasoconstrictions.
- 公益社団法人 日本薬理学会の論文
著者
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MATSUMOTO Mitsuharu
Department of Veterinary Anatomy, Faculty of Agriculture, Kagoshima University
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Nishio Akira
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Obi Takeshi
Department of Veterinary Pharmacology, Faculty of Agriculture, Kagoshima University
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OBI Takeshi
Department of Animal Science, Faculty of Agriculture, University of the Ryukyus
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MATSUMOTO Mitsuharu
Department of Basic Veterinary Science, Faculty of Agriculture, Kagoshima University
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