Efficacy of Gefitinib for Elderly Patients with Advanced Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor Gene Mutations: A Retrospective Analysis
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概要
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Objective To retrospectively evaluate the efficacy and safety of gefitinib in elderly patients with advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor mutations. Methods and Patients Nine patients aged 70 years or older who had advanced NSCLC with mutations of the epidermal growth factor receptor gene were treated with gefitinib, 250 mg daily. Clinical data, types of epidermal growth factor receptor mutations, efficacy and toxicity of gefitinib were evaluated in these patients. Tumor responses were assessed by computed tomography scan using the Response Evaluation Criteria in Solid Tumors. Results Six patients showed a partial response, and the other three exhibited stable disease. The overall response rate was 66.7%. The median progression-free survival was 396 days, whereas the median over all survival was 523 days. No serious toxicities were observed. Conclusion Gefitinib is very efficacious and safe for elderly patients with adenocarcinoma of the lung harboring an EGFR tyrosine kinase mutation. The present data support the use of gefitinib in this particular subgroup.
著者
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Miyamoto Atsushi
Department Of Cardiovascular Medicine School Of Medicine Hokkaido University
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Kishi Kazuma
Department Of Respiratory Medicine Respiratory Center
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Yoshimura Kunihiko
Department Of Respiratory Medicine Respiratory Center Toranomon Hospital
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Kurosaki Atsuko
Department Of Diagnostic Radiology Toranomon Hospital
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Kishi Kazuma
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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Takaya Hisashi
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Japan
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Morokawa Nasa
Department of Respiratory Medicine, Respiratory Center, Japan
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Uruga Hironori
Department of Respiratory Medicine, Respiratory Center, Japan
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Uruga Hironori
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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Miyamoto Atsushi
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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Beika Yuka
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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Enomoto Takahiro
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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