Determination of Epidemiology of Clinically Isolated Cryptococcus neoformans Strains in Japan by Multilocus Sequence Typing
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概要
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Cryptococcus neoformans and Cryptococcus gattii are the causative agents of cryptococcosis. Despite its importance, our knowledge of the epidemiology of cryptococcosis in Japan remains limited. To establish an epidemiological database on cryptococcosis in Japan, we determined the genetic variability of 44 Japanese clinical isolates of C. neoformans (var. grubii: serotype A) by multilocus sequence typing (MLST). The strains were clinically isolated from 1992 to 2011 in 5 different areas of Japan (the Hokkaido region [n = 1], Kanto region [n = 32], Chubu region [n = 1], Kansai region [n = 1], and Kyushu region [n = 9]). According to the method recommended by the International Society for Human and Animal Mycology cryptococcal genotyping working group, 36 isolates (82%) were identified as sequence type (ST)46. The remaining strains belonged to ST45 (n = 1) and ST47 (n = 1), and 6 isolates belonged to novel independent STs. There was little geographic difference in the ST population. Our present data are still limited; however, because most clinical isolates showed the same MLST profile in Japan, applying the current MLST scheme for Cryptococcus may at times be insufficient for investigating the infection route among outbreak cases. To solve this problem, it may be necessary to investigate other gene loci or develop a novel method with greater discriminatory power. However, in cases in which a strain belongs to a minor ST, our data may serve as useful epidemiological information in Japan.
著者
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TAKEMURA Hiromu
Department of Laboratory Medicine, Nagasaki University School of Medicine
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Ohno Hideaki
Department Of Cardiovascular Surgery Yokohama National Hospital
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Umeyama Takashi
Department of Bioactive Molecules, National Institute of Infectious Diseases
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Umeyama Takashi
Department Of Biotechnology Graduate School Of Agriculture And Life Sciences The University Of Tokyo
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Umeyama Takashi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Kishi Kazuma
Department Of Respiratory Medicine Respiratory Center
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TANABE Koichi
Department of Bioactive Molecules, National Institute of Infectious Diseases
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Yamagoe Satoshi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Minamoto Fujihiko
Department Of Clinical Laboratory Medicine Institute Of Medical Science University Of Tokyo
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Tanamachi Chiyoko
Department Of Laboratory Medicine Kurume University Hospital
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Fujii Takeshi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Watanabe Hiroshi
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical And Dental Science
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Miyazaki Yoshitsugu
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Takagi Taeko
Department Of Clinical Laboratory St. Marianna University School Of Medicine
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Takemura Hiromu
Department of Microbiology, St. Marianna University School of Medicine
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Kishi Kazuma
Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital
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KANEKO Yukihiro
Department of Cardiothoracic Surgery and the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Tanamachi Chiyoko
Department of Clinical Laboratory Medicine, Kurume University Hospital
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Yamagoe Satoshi
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
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