Histopathological Study of Murine Pulmonary Cryptococcosis Induced by Cryptococcus gattii and Cryptococcus neoformans
スポンサーリンク
概要
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Although Cryptococcus gattii can cause life-threatening complications, putative virulence factors of C. gattii remain controversial. Therefore, we conducted the present study to elucidate the virulence factors of the yeast and found that the mortality rate of mice infected with C. gattii R265 was significantly higher than that of those infected with C. gattii 5815; however, no difference was found in the mortality rates between mice infected with C. gattii R265 and Cryptococcus neoformans H99. In contrast, we found a significant difference in histopathological findings of the lungs between mice infected with C. gattii R265 and C. neoformans H99. The former showed alveolar expansion due to yeast proliferation with much lesser macrophage response, whereas the latter showed numerous nodules in the alveolar space consisting of macrophages and multinucleated giant cells. Furthermore, alveolar expansion was more enhanced in mice infected with C. gattii R265 than in those infected with C. gattii 5815. Our study confirmed that there is a different pathophysiology leading to death during C. gattii and C. neoformans infections. The result can provide two characteristics of C. gattii: one includes some mechanisms to escape from host recognition via macrophage and another includes a high performance of pulmonary structural alteration. These characteristics may be associated with the high virulence of C. gattii.
著者
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SHINOZAKI Minoru
Department of Surgical Pathology, Toho University School of Medicine
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Yamamoto Shuhei
Department Of Chemistry Graduate School Of Science Osaka City University
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Ohno Hideaki
Department Of Cardiovascular Surgery Yokohama National Hospital
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Tochigi Naobumi
Department Of Molecular Pathology Graduate School Of Medicine Chiba University
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Nemoto Tetsuo
Department Of Clinical Pathology Tokyo Medical And Dental University Graduate School
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Umeyama Takashi
Department of Bioactive Molecules, National Institute of Infectious Diseases
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Umeyama Takashi
Department Of Biotechnology Graduate School Of Agriculture And Life Sciences The University Of Tokyo
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Umeyama Takashi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Nakayama Haruo
Department Of Material Science Faculty Of Engineering Yokohama National University
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TANABE Koichi
Department of Bioactive Molecules, National Institute of Infectious Diseases
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Yamagoe Satoshi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Shibuya Kazutoshi
Department Of Clinical Pathology School Of Medicine Toho University
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Wakayama Megumi
Department Of Pathology Ohashi Hospital Toho University School Of Medicine
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Yamamoto Yoshiro
Department Of Chemistry The University Of Tokyo
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Shinozaki Minoru
Department Of Surgical Pathology Toho University School Of Medicine
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Okubo Yoichiro
Department Of Surgical Pathology Toho University Omori Medical Center
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Kamei Katsuhiko
Division Of Clinical Research Medical Mycology Research Center Chiba University
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Miyazaki Yoshitsugu
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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KANEKO Yukihiro
Department of Cardiothoracic Surgery and the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Sasai Daisuke
Department of Surgical Pathology, Toho University School of Medicine
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Ishiwatari Takao
Department of Surgical Pathology, Toho University School of Medicine
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Shimodaira Kayoko
Department of Surgical Pathology, Toho University School of Medicine
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Ishiwatari Takao
Department of Surgical Pathology, Toho University Omori Medical Center
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Wakayama Megumi
Department of Surgical Pathology, Toho University School of Medicine
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Sasai Daisuke
Department of Surgical Pathology, Toho University Omori Medical Center
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Yamamoto Yoshiro
Department of Surgical Pathology, Toho University School of Medicine
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Tanabe Koichi
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
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Nakayama Haruo
Department of Neurosurgery, Toho University Ohashi Medical Center
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Nakayama Haruo
Department of Chemistry, Faculty of Engineering, Yokohama National University
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Nakayama Haruo
Department of Applied Chemistry, Faculty of Engineering, Yokohama National University
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Yamagoe Satoshi
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
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