An Outbreak of Histoplasmosis among Healthy Young Japanese Women after Traveling to Southeast Asia
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概要
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Histoplasmosis, caused by Histoplasma capsulatum, is an endemic mycosis in many countries of the world except for Japan. Outbreaks of histoplasmosis among Japanese people are very rare and are mainly imported by travelers. We report an outbreak of histoplasmosis among healthy Japanese people who traveled to a resort area in Southeast Asia. Three young Japanese women traveled to Langkawi island, Malaysia and stayed on the island for five days without visiting caves, a known reservoir of H. capsulatum. All three individuals developed flu-like symptoms with multiple nodule shadows on chest X rays or chest CT scans at around ten days after their return to Japan. Serum samples obtained from the three subjects were positive for anti-Histoplasma antibody and specific PCR for H. capsulatum on lung biopsy specimens and the serum from one patient was positive. The clinical course of all three patients improved without the use of anti-fungal agents and no recurrence has been confirmed. Clinical attendants should consider histoplasmosis when they see patients with flu-like symptoms with abnormal chest X-rays after visiting H. capsulatum endemic areas, especially Southeast Asia.
著者
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Ohno Hideaki
Department Of Cardiovascular Surgery Yokohama National Hospital
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Sata Tetsutaro
Department Of Pathology Aids Research Center National Institute Of Infectious Diseases
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Ishida-okawara Akiko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Yamagoe Satoshi
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Nagata Noriyo
Department Of Pathology National Institute Of Infectious Diseases
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Horino Atsuko
Department Of Safety Research On Biologics National Institute Of Infectious Diseases
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Arakawa Yoshichika
Department Of Bacterial And Blood Products National Institute Of Health
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Tsuji Takahiro
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Watanabe Akira
Division Of Control And Treatment Of Infectious Diseases Chiba University Hospital
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Hasegawa Hideki
Department Of Computer Science And Electronics Kyushu Institute Of Technology
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Kamei Katsuhiko
Division Of Clinical Research Medical Mycology Research Center Chiba University
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Miyazaki Yoshitsugu
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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KANEKO Yukihiro
Department of Cardiothoracic Surgery and the Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo
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Tsuji Takahiro
Department of Pathology, National Institute of Infectious Diseases
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Ogata Yoshiko
National Hospital Organization, Yamaguchi-Ube Medical Center
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Suguro Hajime
Department of Respiratory Medicine, Yokohama Social Insurance Chuo Hospital
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Yokota Soichiro
Division of Respiratory Disease, National Hospital Organization Toneyama National Hospital
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Yamane Kunikazu
Department of Bacteriology II, National Institute of Infectious Diseases
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Horino Atsuko
Department of Bacteriology II, National Institute of Infectious Diseases
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