Early Mortality Following Intracerebral Infection with Tick-Borne Encephalitis Virus Oshima Strain in a Mouse Model
スポンサーリンク
概要
- 論文の詳細を見る
Tick-borne encephalitis virus (TBEV) is a zoonotic agent which causes acute central nervous system (CNS) disease in humans. In this study, we examined the pathogenic process following intracerebral infection with TBEV Oshima strain in a mouse model. Intracerebral infection resulted in dose-dependent mortality, and all mice died following challenge with 102 PFU or more of virus within 10 days. Acutely necrotic neurons and widespread inflammation were observed throughout the CNS. We therefore conclude that mortality following intracerebral infection results from a direct CNS pathology.
著者
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Hasegawa Hideki
Department Of Electrical Engineering Faculty Of Engineering Hokkaido University:department Of Electr
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Nagata Noriyo
National Inst. Infectious Diseases Tokyo
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SATA Tetsutaro
Department of Pathology, National Institute of Infectious Diseases
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Hayasaka Daisuke
Department of Virology, Institute of Tropical Medicine, Nagasaki University
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Nagata Noriyo
Department of Pathology, National Institute of Infectious Diseases
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TAKASHIMA Ikuo
Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Vet
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KOIKE Satoshi
Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Researc
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Sata Tetsutaro
Department Of Pathology Aids Research Center National Institute Of Infectious Diseases
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Takashima Ikuo
Laboratory Of Public Health Department Of Environmental Veterinary Sciences Graduate School Of Veter
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Hasegawa Hideki
Department Of Electrical Engineering Faculty Of Engineering Hokkaido University
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Nagata Noriyo
Department Of Pathology National Institute Of Infectious Diseases
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Hasegawa Hideki
Department Of Computer Science And Electronics Kyushu Institute Of Technology
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KOIKE Satoshi
Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research
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