Human Papillomavirus (HPV) in Papilloma, Leukoplakia and Squamous Cell Carcinoma of the Oral Cavity
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概要
- 論文の詳細を見る
To clarify pathogenic roles of human papillomavirus (HPV) in tumorigenesis, 111 specimens of oral lesions were examined by Southern blot hybridization (SBH) and polymerase chain reaction (PCR) using a set of primers, L1C1/LlC2 and L1C2 m (L1-PCR). The specimens consisted of 9 papillomas, 34 leukoplakias, 36 squamous cell carcinomas (SCC), 12 fibrous polyps, 6 epulis fibrosas and granulomatosas, 8 normal mucosa collected at operation, and 6 normal tongues taken at autopsy. HPV DNA was detected not by SBH but by PCR with higher frequency in papilloma (5/9; 55.6%), as compared with in leukoplakia (7/34; 20.6%), SCC (7/36; 19.4%), fibrous polyp (3/12; 25%), normal mucosa at operation (1/8; 12.5%) and at autopsy (3/6; 50%). By direct sequencing of the PCR products for genotyping in 26 HPV DNA-positive specimens, HPV-18 was detected in 23 (88.5%), -59 in 2(7.7%) and -70 in 1(3.8%). HPV-70 was first identified in the oral papilloma lesions.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 1999-06-20
著者
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Sata T
Departments Of Pathology Aids Research Center National Institute Of Infectious Diseases:laboratory O
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Sata Tetsutaro
Department Of Pathology Aids Research Center National Institute Of Infectious Diseases
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Terai M
Tokushima Univ. Tokushima Jpn
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寺井 政憲
東京医科歯科大学歯学部口腔病理学
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Takagi Minoru
Department Of Anatomy Dental Research Center Nihon University School Of Dentistry
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Terai Masanori
Department Of Oral Pathology Faculty Of Dentistry Tokushima University
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Terai Masanori
Department Of Oral Pathology Faculty Of Dentistry Tokyo Medical And Dental University:departments Of
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Matsukura Toshihiko
Virology And Aids Research Center National Institute Of Infectious Diseases
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