Differential Expression of Notch Genes in the Neurogenesis of Mouse Embryos
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概要
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This paper's purpose is to analyze temporally and spatially differential roles of Notch-1, -2 and -3 in the neurogenesis of mouse embryos. In Northern blot hybridization, Notch-1 and -3 were expressed in the nervous tissue and increased in the level from 12 to 14 day post coitum (dpc). Notch-2 was more weakly expressed than Notch-1 and -S on 12 and 14 dpc. In in situ hybridization, Notch-1 and -3 expressions appeared early on 6 dpc. On 12, 14, and 15 dpc, high level of Notch-1 expression was observed in the ventricular zone, and Notch-3 was diffusely expressed in the ventricular, intermediate and marginal zones of the brain, and Notch-2 expression was in the lower level. These findings suggest that Notch-1, -2 and -3 play individually complementary and combinatorial roles in the neurogenesis of mouse embryos.
- 特定非営利活動法人日本臨床口腔病理学会の論文
著者
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Takagi Minoru
Department of Anatomy, Nihon University School of Dentistry
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SAKAMOTO Kei
Department of Gastroenterology, University of Tokyo
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Takagi Minoru
東京医科歯科大学 院 口腔機能再建学 講座 分子病態学
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Takagi Minoru
Department Of Oral Surgery Nihon University School Of Dentistry At Matsudo
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KATSUBE Ken-ichi
Department of Molecular Pathology, Tokyo Medical and Dental University (TMDU)
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Sakamoto Kei
東京医科歯科大学 医歯総研究 分子病態
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Sakamoto K
東京医科歯科大学 医歯総合研究 分子病態
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KAYANO Teruo
Department of Oral Pathology, Faculty of Dentistry, Tokyo Medical and Dental University
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Takagi Minoru
Iwate Fisheries Technology Center
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Sakamoto Kei
Department Of Cardiovascular Medicine University Of Tokyo Graduate School Of Medicine
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Takagi Minoru
Department Of Anatomy Dental Research Center Nihon University School Of Dentistry
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Kayano Teruo
Department Of Oral Pathology Faculty Of Dentistry Tokyo Medical And Dental University
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Katsube K
Molecular Pathology Department Of Oral Resttitution Division Of Oral Health Sciences
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Qu Yiwen
Department of Oral Pathology, Faculty of Dentistry, Tokyo Medical and Dental University
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Qu Yiwen
Department Of Oral Pathology Faculty Of Dentistry Tokyo Medical And Dental University
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Tekeda Shin'ichi
Faculty Of Dentistry Tokyo Medical And Dental University
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Takagi M
Iwate Fisheries Technol. Center
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Katsube Ken-ichi
Department of Molecular Pathology, Graduate School of Tokyo Medical and Dental University
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