Human Papillomavirus in Oral Cancer from Sri Lanka : Prevalence and relationship with clinico-pathological parameters
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概要
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The presence of human papillomavirus (HPV) in two groups of oral squamous cell carcinoma (OSCC) from Sri Lanka were analyzed by PCR and direct cycle sequencing using consensus GP5+/6+ primers. The two groups of OSCC specimens analyzed were 68 formalin-fixed paraffin-embedded surgical specimens and 34 formalin-fixed unembedded biopsies. Twenty-five patients from the latter group were habitual betel quid chewers. The HPV prevalence of the overall sample was 38/102 (37.2%). However, HPV was detected in significantly higher rate from formalin-fixed unembedded biopsies (61.7%) compared to paraffin embedded surgical specimens (25%) (p<0.0003). Upon sequencing, high-risk HPV types, 16,18, 45 and 66 were detected in 65% of the HPV infected tumors. Moreover, HPV was detected at significantly higher rates from small primary tumors (T1&T2) (75%) compared to large primary tumors (T3&T4) (30%) (p<0.025). However, no correlation existed between other clinico-pathological variables such as age, gender, sites, habits or histological differentiation and HPV detection when analyzed statistically using Pearson's chi-square test (at 5% level of significance). In conclusion, high prevalence of HPV in formalin fixed-unembedded OSCC biopsies from Sri Lanka indicate that, in addition to betel quid, viral infection may play a role in oral carcinogenesis and support the multi-factor model for oral cancer causation.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2003-06-25
著者
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TAGAMI Junji
Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and
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TAKAGI Minoru
Molecular Pathology, Department of Oral Resttitution, Division of Oral Health Sciences
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Tagami Junji
Cariology & Operative Dentistry Department Of Restorative Dentistry Tokyo Medical And Dental Uni
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Terai M
Tokushima Univ. Tokushima Jpn
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of Restor
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寺井 政憲
東京医科歯科大学歯学部口腔病理学
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Takagi M
Molecular Pathology Department Of Oral Restitution Tokyo Medical And Dental University
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Jayasooriya Primali
Cariology & Operative Dentistry, Department of Restorative Dentistry, Tokyo Medical and Dental Unive
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Kurose Kazuyo
Molecular Pathology, Department of Oral Restitution, Tokyo Medical and Dental University
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Terai Masanori
Department of Oral Pathology, Faculty of Dentistry, Tokushima University
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Sivagnanam Kandavanam
Maharagama National Cancer Institute
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Siriwardana Samadarani
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya
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Tilakaratne Wanninayaka
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya
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Kurose K
Molecular Pathology Department Of Oral Restitution Tokyo Medical And Dental University
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Terai Masanori
Department Of Oral Pathology Faculty Of Dentistry Tokushima University
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Terai Masanori
Department Of Oral Pathology Faculty Of Dentistry Tokyo Medical And Dental University:departments Of
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Jayasooriya Primali
Cariology & Operative Dentistry Department Of Restorative Dentistry Tokyo Medical And Dental Uni
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Siriwardana Samadarani
Department Of Oral Pathology Faculty Of Dental Sciences University Of Peradeniya
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Tilakaratne Wanninayaka
Department Of Oral Pathology Faculty Of Dental Sciences University Of Peradeniya
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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