Immunohistochemical Distribution Pattern of Desmocollin 3, Desmocollin 1 and Desmoglein 1, 2 in the Pemphigus of Oral Mucosa and Skin
スポンサーリンク
概要
- 論文の詳細を見る
Pemphigus is an autoimmune disease in which autoantibodies play a pathogenic role, causing loss of epithelial cell adhesion with resulting blister formation.In the present study, the distribution patterns of desmocollin 3(Dsc 3), desmocollin 1(Dsc 1)and desmoglein 1 and 2(Dsg 1, 2)in pemphigus vulgaris(PV)and pemphigus erythematosus(PE)were investigated by immunohistochemistry.Dsc 3 was distributed at the cell membrane of the basal and suprabasal layers of the normal oral mucosa and skin epithelium.Dsc 1 was distributed only at the cell membrane of the upper spinous layers of normal skin, and was not visible in normal oral mucosa epithelium.Dsg 1, 2 was distributed at the cell membrane of the suprabasal layers of normal oral mucosa and skin epithelium.The distribution of Dsc 3 and Dsg 1, 2 was obviously sparser in the oral PV and cutaneous PV than in normal control epithelium.Internalization of Dsc 3, Dsc 1 and Dsg 1, 2 occurred specifically in PV and PE, giving staining patterns resembling cytoplasmic patchy granules, rings and dense clumps.Internalization of Dsc 3 was more frequent in cutaneous PV(60%)and PE(60%)than in oral PV(30%).These findings suggest that internalization of Dsc 3 is closely associated with disease duration(P<0.01)and disease severity(P<0.05)in PV, and that not only desmogleins but also desmocollins may play an etiological role.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2000-12-20
著者
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TAKAGI Minoru
Molecular Pathology, Department of Oral Resttitution, Division of Oral Health Sciences
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OKADA Norihiko
Diagnostic Oral Pathology, Department of Oral Restitution, Pulp Biology and Endodontics, Department
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Wei-Wen Jiang
Molecular Pathology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate Scho
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of Restor
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Ling-yun Li
Dermatology Research Institute Of Shenyang Shenyang People's Republic Of China
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Wei-wen Jiang
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Li-hong Wang
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Okada Norihiko
Diagnostic Oral Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of
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Okada N
Department Of Clinical Laboratory Faculty Of Dentistry Tokyo Medical And Dental University
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Katube Ken-ichi
Molecular Pathology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate Scho
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Katube Ken-ichi
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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