Detection of p53, Bax, Rb, p16 and Human Papillomavirus DNA in Betel Quid Associated Oral Squamous Cell Carcinoma in Myanmar
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概要
- 論文の詳細を見る
Chronic betel quid chewing has a strong correlation with oral cancer. In order to examine relationship of p53 and p16, and the prevalence of human papillomavirus (HPV), we studied p53, Bax, p16^<INK4a>, Rb and HPV prevalence using forty-seven cases of betel quid associated oral squamous cell carcinoma (OSCC) in Myanmar. HPV was detected by polymerase chain reaction (PCR), using primers MY09 / MY11 and L1C1 / L1C2 and LlC2m. Immunohistochemically, 59.6% were p53-positive and Bax-negative, and 68.0% were p16^<INK4a>-negative and Rb-positive. HPV DNA was detected in only 14.9% of all OSCCs. The expression of p53/Bax relation (P<0.01) and p16^<INK4a>/Rb relation (P<0.001) were found in betel quid associated OSCCs when compared with normal mucosa. Therefore, betel quid plays a critical role in oral carcinogenesis in Myanmar.
- 特定非営利活動法人日本臨床口腔病理学会の論文
- 2003-03-25
著者
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TAKAGI Minoru
Molecular Pathology, Department of Oral Resttitution, Division of Oral Health Sciences
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Myint B
Department Of Oral Medicine And Pathology Institute Of Dental Medicine
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Nishioka Mai
Molecular Pathology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate Scho
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Win Swe
Department of Oral Medicine and Pathology, Institute of Dental Medicine
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Myint Ba
Department of Oral Medicine and Pathology, Institute of Dental Medicine
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Pulp Biology And Endodontics Department Of Restor
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Win Swe
Department Of Oral Medicine And Pathology Institute Of Dental Medicine
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Nishioka M
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Nishioka Mai
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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Takagi Minoru
Molecular Pathology Department Of Oral Restitution Division Of Oral Health Sciences Graduate School
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