Histopathological Evaluation of the Efficacy of Antifungals for Experimental Trichosporon Bloodstream Infection
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概要
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The efficacy of polyene macrolides to treat experimental Trichosporon bloodstream infection was evaluated by histopathological examination and viable cell counts in the kidneys of infected mice. Viable cell counts on the 5th day after infection confirmed that liposomal amphotericin B (L-AMB) is a more effective treatment than fluconazole (FLC) for mice infected with an azole-resistant strain of Trichosporon. Histological examination revealed that the administration of L-AMB induced a transformation from acute purulent inflammation caused by both azole-susceptible and -resistant strain infections to a chronic and subsiding form, whereas FLC failed to convert the acute inflammation induced by the azole-resistant strain to a subsiding form. Our results demonstrate that polyene macrolides can be used as an alternative therapy for infection of azole-resistant strains of Trichosporon and that histopathological evaluation is useful for elucidating the pathophysiology of an experimental Trichosporon infection.
著者
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Hasegawa Chikako
Department Of Pathology Omori Hospital Toho University School Of Medicine
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Sugita Takashi
Department Of Chest Medicine Institute Of Pulmonary Cancer Research School Of Medicine Chiba Univers
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Tochigi Naobumi
Department Of Molecular Pathology Graduate School Of Medicine Chiba University
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Nemoto Tetsuo
Department Of Clinical Pathology Tokyo Medical And Dental University Graduate School
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Mitsuda Aki
Department Of Pathology Omori Hospital Toho University School Of Medicine
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Murayama Somay
Laboratory Of Molecular Epidemiology For Infectious Agents Graduate School Of Infection Control Scie
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Shibuya Kazutoshi
Department Of Clinical Pathology School Of Medicine Toho University
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Wakayama Megumi
Department Of Pathology Ohashi Hospital Toho University School Of Medicine
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Shimamura Tsuyoshi
Department Of General Surgery Hokkaido University School Of Medicine
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Shinozaki Minoru
Department Of Surgical Pathology Toho University School Of Medicine
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Okubo Yoichiro
Department Of Surgical Pathology Toho University Omori Medical Center
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Sasai Daisuke
Department of Surgical Pathology, Toho University School of Medicine
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Shinozaki Minoru
Department of Surgical Pathology, Toho University Omori Medical Center
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Ishiwatari Takao
Department of Surgical Pathology, Toho University School of Medicine
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Kaneko Takehiko
Laboratory of Human Nutrition, Wayo Women's University
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Ishiwatari Takao
Department of Surgical Pathology, Toho University Omori Medical Center
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Wakayama Megumi
Department of Surgical Pathology, Toho University Omori Medical Center
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Mitsuda Aki
Department of Surgical Pathology, Toho University Omori Medical Center
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Sasai Daisuke
Department of Surgical Pathology, Toho University Omori Medical Center
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Shimamura Tsuyoshi
Department of Surgical Pathology, Toho University Omori Medical Center
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Tochigi Naobumi
Department of Surgical Pathology, Toho University Omori Medical Center
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Murayama Somay
Laboratory of Molecular Cell Biology, School of Pharmacy, Nihon University
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Kaneko Takehiko
Laboratory of Human Nutrition, Wayo Women's University
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