Treatment of Onychomycosis Using a 1064nm Nd : YAG Laser
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概要
- 論文の詳細を見る
We investigated the efficacy of 1064nm Nd:YAG laser for the treatment of onychomycosis caused by dermatophytes. The study population consisted of 12 patients (6 male, 6 female ; average age 53.5 years), with onychomycosis confirmed by fungal culture and/or real-time PCR identification of the pathogen. The causative agent was identified as <I>Trichophyton rubrum</I> in 11 cases and a mixture of <I>T. rubrum</I> and <I>T. mentagrophytes</I> in 1 case. For each patient, laser treatment was given to a single hallux nail, with turbidity at baseline affecting <75% of the nail surface and thickness at baseline <3mm. Treatment was given in 3 sessions at 4-week intervals, and nail turbidity was evaluated 3 and 6 months after the first laser treatment. After 6 months the efficacy results were as follows : 3 cases, turbidity significantly improved ( >70%) ; 2 cases, turbidity improved (50-70%), 1 case, turbidity slightly improved (30-50%) ; 5 cases, no change in turbidity (<30% improvement) ; and 1 case, turbidity worsened. Overall, the total lesion area with turbidity in 12 patients decreased from 664.4mm<SUP>2</SUP> to 481.0mm<SUP>2</SUP>, corresponding to a 27.6% improvement after treatment. Pain during laser treatment was well tolerated, and all patients underwent all 3 treatments. These results suggest that the 1064nm Nd:YAG laser could be a useful treatment alternative for patients with mild onychomycosis.
- 日本医真菌学会の論文
著者
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Miyata Keishi
Department Of Cell Differentiation The Sakaguchi Laboratory School Of Medicine Keio University
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Sugita Takashi
Department Of Chest Medicine Institute Of Pulmonary Cancer Research School Of Medicine Chiba Univers
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Noguchi Hiromitsu
Noguchi Dermatology Clinic
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Hiruma Masataro
Ochanomizu Institute for Medical Mycology and Allergology
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Hiruma Midori
Department of Dermatology, Juntendo University School of Medicine
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Miyata Keishi
Department of Immunology, Allergy & Vascular Biology, Kumamoto University
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