In Vitro Activities of Azole Antifungal Agents against Propionibacterium acnes Isolated from Patients with Acne Vulgaris

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概要

• 論文の詳細を見る

• The Gram-positive bacterium Propionibacterium acnes is the causative agent of acne vulgaris. Antibiotics such as tetracycline and macrolide derivatives are used to treat this skin disease; however, the isolation frequency of antibiotic-resistant P. acnes has been increasing. The anti-P. acnes activity of imidazole antifungal agents was reported more than 20 years ago, and since then, new azole antifungal agents have been marketed. Thus, this study determined the in vitro activities of azole antifungal agents against P. acnes isolated from patients with acne vulgaris. Of the five agents tested, miconazole, ketoconazole, and itraconazole showed concentration-dependent anti-P. acnes activity, including against antibiotic-resistant isolates. Time-kill assay also showed the time-dependent activity of the drugs. Fluconazole and voriconazole showed no anti-P. acnes activity.

• 公益社団法人　日本薬学会の論文

著者

• TSUBOI Ryoji

  Department of Dermatology, Juntendo University School of Medicine

• SUGITA Takashi

  Department of Microbiology, Meiji Pharmaceutical University

• TAKATORI KAZUHIKO

  Department of Medicinal Chemistry, Meiji Pharmaceutical University

• Shinoda T

  Teikyo University Institute Of Medical Mycology

• Sugita Takashi

  Department Of Microbiology Meiji Pharmaceutical University

• Sugita Takashi

  Department Of Chest Medicine Institute Of Pulmonary Cancer Research School Of Medicine Chiba Univers

• NISHIKAWA Akemi

  Department of Immunobiology, Meiji Pharmaceutical University

• IKEDA Reiko

  Department of Microbiology, Meiji College of Pharmacy

• Ikeda Reiko

  Department Of Microbiology Meiji College Of Pharmacy

• Nishikawa Akemi

  Department Of Immunobiology Meiji Pharmaceutical University

• Sugita T

  Department Of Microbiology Meiji Pharmaceutical University

• Tsuboi Ryoji

  Department Of Dermatology Juntendo University School Of Medicine

• Miyamoto Mayumi

  Department of Immunobiology, Meiji Pharmaceutical University

• Takatori Kazuhiko

  Department Of Medicinal Chemistry Meiji College Of Pharmacy

• Miyamoto Mayumi

  Department Of Dermatology Tokyo Medical University

• Takatori Kazuhiko

  Department of Organic Chemistry, Meiji Pharmaceutical University

• Tsuboi Ryoji

  Department of Immunobiology, Meiji Pharmaceutical University

• Nishikawa Akemi

  Department of Dermatology, Tokyo Medical University

• Ikeda Reiko

  Department of Environmental Sciences, Faculty of Science, Ibaraki University

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