Calcineurin Homologous Protein Isoform 2 (CHP2), Na^+/H^+ Exchangers-Binding Protein, Is Expressed in Intestinal Epithelium
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概要
- 論文の詳細を見る
The Na^+/H^+ exchangers (NHEs) comprise a family of membrane proteins that catalyze the electroneutral exchange of Na^+ and H^+. Calcineurin homologous protein (CHP) acts as a crucial cofactor for NHE activity through direct interaction with the carboxyl-terminal tail region of NHEs. We have cloned a new rat CHP isoform (rCHP2) and characterized the binding property to NHEs and the tissue distribution. rCHP2 binds to the juxtamembrane region of plasma membrane-type NHE isoforms (NHE1-5) in vivo and in vitro as well as rCHP1 (original rat CHP). Interestingly, CHP2 is predominantly expressed in the small and large intestine although rCHP1 shows relatively ubiquitous expression at both the mRNA and protein levels. In situ hybridization experiments demonstrated the abundant expression of CHP2 in the epithelial cell layer of villi of the small intestine in contrast with the expression of CHP1 in both the epithelial layer and connective tissues. These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s).
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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NAKAMURA Yutaka
Department of Industrial and Systems Engineering, Setsunan University
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NAKAMURA NORIHIRO
Department of Geoenvironmental Science, Graduate School of Science, Tohoku University
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INOUE Hiroki
Department of Public Health, Graduate School of Medicine, Chiba University
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Masuda Masao
Faculty Of Pharmaceutical Sciences Kyoto University
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KANAZAWA Hiroshi
Department of Biology, Graduate School of Science, Osaka University
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Kanazawa H
Department Of Biological Sciences Graduate School Of Science Osaka University
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Kanazawa Hiroshi
Department Of Biological Sciences Graduate School Of Science Osaka University
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Nakamura Norifumi
President's Office Yoshitomi Pharmaceutical Industries Ltd.
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Nakamura Norihiro
Department Of Biological Sciences Graduate School Of Science Osaka University
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Takai T
Department Of Biological Science Graduate School Of Science Osaka University
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Masada M
Department Of Biological Science Graduate School Of Science Osaka University
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NAGITA Mana
Department of Biological Sciences, Graduate School of Science, Osaka University
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TAKAI Tomoyo
Department of Biological Science, Graduate School of Science, Osaka University
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MASUDA Miho
Department of Biological Science, Graduate School of Science, Osaka University
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Nagita Mana
Department Of Biological Sciences Graduate School Of Science Osaka University
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Inoue Hiroki
Department Of Biological Sciences Graduate School Of Science Osaka University
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Nakamura Yutaka
Niigata Univ. Of Pharmacy And Applied Life Sciences
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Nakamura Yutaka
Department Of Animal Sciences Ibaraki University
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Nakamura Norihiro
Department of Biological Science, Graduate School of Science, Osaka University
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